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Supplementation of Vitamin D in Patients with Pulmonary Tuberculosis Ethnic Batak

机译：肺结核患者维生素D补充肺结核族蝙蝠侠

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Vitamin D has a complex action on the immune system, among other cathelicidin production stimulator which enhances phagocytosis magrofag. TB is an infectious disease which causes high mortality and morbidity in the world. Vitamin D will give the effect when it binds to its receptor (VDR). Variants VDR gene polymorphism associated with susceptibility and resistance to pulmonary tuberculosis. Objective: to determine the effect of vitamin D in patients with pulmonary tuberculosis against ethnic Batak The study design with RCT, Ninety-two people with pulmonary TB smear positive new cases of ethnic Batak in Medan were randomized to receive 100,000 IU doses administered at 4 doses. Assessment were performed at 14, 28, 42, and 56 days. Levels of vitamin D beginning and end checked with ELISA techniques and ApaI polymorphisms of genes RVD checked by PCR RFLP. After two months of 86 patients who met the inclusion criteria as many as 40 people with vitamin D intervention and 46 to placebo. Sputum conversion times faster intervention group than placebo (p <0.05) with increased levels of vitamin D is much different (95.31% and placebo interventions 6.81%). 5) dengan peningkatan kadar vitamin D jauh berbeda (intervensi 95,31% dan plasebo 6,81%). Sputum conversion based Apal VDR gene polymorphisms in the two groups was not significant (p> 0.05). Vitamin D proven to accelerate the conversion of sputum in the study population of patients with pulmonary TB ethnic Batak. Apal polymorphism of the VDR gene genotype Aa and aa more conversions at 42 days while the AA genotype at 56 days.
机译：维生素D对免疫系统具有复杂的作用，其中包括加强吞噬蛋白的制作刺激剂，其增强了吞噬作用。 TB是一种传染病，导致世界上的高死亡率和发病率。当它与其受体（VDR）结合时，维生素D会产生效果。变异VDR基因多态性与易感性和肺结核抗性相关。目的：鉴定维生素D对肺结核患者对肺结核患者的影响，患有RCT的研究设计，患有肺结核的肺结核淋巴淋巴结肌肉淋巴结阳性新病例，随机培养，以获得4剂施用100,000剂量的IU剂量。评估在14,28,42和56天内进行。用PCR rFlp检查的ELISA技术和ELISA技术和APAI多态性检查的维生素D的水平和结束。经过两个月的86名患者，符合维生素D干预的含有许多患者的纳入标准和46人。痰转化次数快于安慰剂组（P <0.05）随着维生素D水平的增加而异（95.31％和安慰剂干预6.81％）。 5）Dengan Peningkatan Kadar Vitamin d Jauh Berbeda（干预95,31％Dan Plasebo 6,81％）。两组中的痰转化基于的APAL VDR基因多态性不显着（P> 0.05）。维生素D证明加速肺结核患者研究人群痰的转化。 VDR基因基因型AA的APAL多态性AA和AA在42天内的转换，而AA基因型在56天。

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