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首页> 外文会议>International Conference on Bioinformatics and Computational Biology >A Next Generation Sequencing Approach to Analyze Genes Expression in Breast Cancer Stem Cells
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A Next Generation Sequencing Approach to Analyze Genes Expression in Breast Cancer Stem Cells

机译：一种分析乳腺癌干细胞基因表达的下一代测序方法

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Despite progressive development in technologies for breast cancer treatment, many challenging issues still persist. Among these challenges, relapse of breast cancer cells was found to be most critical aspect. These cells have tumor-initiating and metastatic potential. The combination of ALDH+ and CD44+/CD24-is widely recognized as potential biomarker for the identification and characterization of breast cancer stem cells. In recent studies, it has been reported that ALDH+ breast cancer cells are 100 fold more tumorigenic that ALDH-cells. High level of tumorigenicity has been observed in breast cancer cells exhibiting positive expression of CD44 and negative expression of CD24. CD44 expression is significantly correlated with Estrogen Receptor-negative (ER-) breast cancer cells. The association between ALDH+ or CD44+/CD24-with Estrogen Receptor-positive (ER+) breast cancer cells in terms of gene expression still remains unresolved. In the present study, the up- and down-regulation of gene expression have been studied that strongly correlate with ALDH+ or CD44+/CD24-expression in ER- and ER+ breast cancer cells by using next-generation sequencing method. For the effective breast cancer therapy, this novel strategy of targeting significant genes can be used as biomarkers to reduce breast cancer stem cells growth that is likely to suppress breast cancer relapse.
机译：尽管乳腺癌治疗技术进行了渐进式发展，但许多具有挑战性的问题仍然存在。在这些挑战中，发现乳腺癌细胞的复发是最关键的方面。这些细胞具有肿瘤起始和转移性潜力。 ALDH +和CD44 + / CD24的组合是广泛认识为潜在的生物标志物，用于鉴定和表征乳腺癌干细胞。在最近的研究中，据报道，Aldh +乳腺癌细胞是100倍的致瘤瘤细胞。在表现出CD44的阳性表达和CD24的阴性表达的乳腺癌细胞中，在乳腺癌细胞中观察到高水平的肿瘤性。 CD44表达与雌激素受体 - 阴性（ER-）乳腺癌细胞显着相关。在基因表达方面，Aldh +或CD44 + / CD24-与雌激素受体阳性（ER +）乳腺癌细胞之间的关联仍未得到解决。在本研究中，已经研究了基因表达的上调和下调，通过使用下一代测序方法与ER-和ER +乳腺癌细胞中的ALDH +或CD44 + / CD24-表达强烈相关。对于有效的乳腺癌治疗，这种靶向重要基因的新策略可用作生物标志物，以减少可能抑制乳腺癌复发的乳腺癌干细胞生长。

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