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首页> 外文会议>Joint Conference on Chemistry >Characteristics of eugenol loaded chitosan-tripolyphosphate particles as affected by initial content of eugenol and their in-vitro release characteristic
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Characteristics of eugenol loaded chitosan-tripolyphosphate particles as affected by initial content of eugenol and their in-vitro release characteristic

机译：丁糖醇的特征载壳聚糖 - 三聚磷酸颗粒受丁香酚初始含量的影响及其体外释放特性

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摘要

The aim of this research was to determine encapsulation efficiency, loading capacity and controlled release of eugenol loaded chitosan-tpp products which prepared by coaservation method. The characteristic of eugenol-loaded chitosan showed that %EE and % LC increased by increasing the initial eugenol content. The optimum of %EE (72.63%) and %LC (43.96%) were obtained at the ratio of chitosan to eugenol of 1:1.5. The FTIR spectrum showed the characteristic peaks of eugenol appearing on spectrum of eugenol encapsulated and blue-shift in thehydroxyl band from 3425.58 cm~(-1) in chitosan-tpp to 3417.86 cm~4 and 3394.72 cm~(-1) in eugenol loaded chitosan-tpp indicating that eugenol was successfully encapsulated. The surface morphologies of freeze-dried particles with the optimum %EE showed that more surface roughness and porosity than plain particles. Furthermore, the in vitro release of particles with minimum and optimum %EE were also investigated in acid (Simulated Gastric Fluid) and base (Simulated Intestinal Fluid) medium at ambient temperature.
机译：该研究的目的是确定通过旋转方法制备的丁糖醇负载含丁糖烷-TPP产品的封装效率，负载能力和控制释放。由丁醇加载的壳聚糖的特征显示，通过增加初始丁烯醇含量来增加％EE和％LC。以1：1.5的壳聚糖与丁香酚的比例获得％EE（72.63％）和％LC（43.96％）的最佳值。 FTIR光谱显示出在含嘌呤-TPP的3425.58cm〜（-1）中的丁香烯醇的光谱，在含嘌呤醇的3417.86cm〜4和3394.72cm〜（-1）的邻丁香烯醇的光谱，在嘌呤烯醇的磷酚的光谱中出现的特征峰。壳聚糖-TPP表明丁香酚成功包封。用最佳％EE的冷冻干燥颗粒的表面形态表明，比普通颗粒更粗糙和孔隙率更多。此外，在环境温度下，还在酸（模拟胃液）和碱（模拟肠道）培养基中研究了颗粒的体外释放。

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