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首页> 外文会议>International Conference on Pulsed Lasers and Laser Applications >The role of photochemical transformations of tetrahydrobiopterin in the pathogenesis and phototherapy of vitiligo
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The role of photochemical transformations of tetrahydrobiopterin in the pathogenesis and phototherapy of vitiligo

机译：四氢替替替替替素光化学转化在白癜风发病机制和光疗中的作用

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Melanogenesis disorder leads to several pathologies, including vitiligo. Tetrahydrobiopterin (H_4Bip) as the phenylalanine 4-hydroxylase coenzyme catalyzes the oxidation of phenylalanine to tyrosine (a melanin precursor). H_4Bip is easily oxidized by oxygen in vivo and in vitro. Vitiligo is accompanied by three-fivefold increased de-novo synthesis of H_4Bip, its excess and its further oxidation are essential factors in the pathogenesis of vitiligo. We have demonstrated that pterin products of H_4Bip autoxidation (dihydropterin (H_2Ptr), dihydroxanthopterin and pterin) predominate over biopterin products (dihydrobiopterin (H_2Bip) and biopterin). It was shown that ultraviolet (UV) irradiation accelerates the autoxidation while the products of oxidative degradation of H_4Bip act as photosensitizers. Photosensitized oxidation of H_4Bip can contribute to the pathogenesis of vitiligo. The main distinguishing feature of UV photooxidation of H_4Bip from autoxidation was the formation of dihydropterin (H_2Ptr)_2 and dihydrobiopterin (H_2Bip)_2 dimers. Here we reported on the dependences of the photodimerization reaction on the wavelength and intensity of radiation using xenon lamps and UV tunable lasers as sources of UV radiation. It was shown that UV irradiation with a laser is more efficient than that with xenon lamp. It was established that the greatest number of dimers were formed by irradiating the H_4Bip solution by radiation with a wavelength in the range 308-312 nm. The data obtained are discussed in the context of UVB narrowband vitiligo phototherapy.
机译：糖素生成障碍导致几种病理，包括白癜风。作为苯丙氨酸4-羟化酶辅酶催化苯丙氨酸氧化至酪氨酸（黑色素前体）的四氢萘替肽素催化。 H_4bip通过体内和体外氧气容易氧化。白癜风伴随着35fold的增加的H_4bip合成，其过量及其进一步的氧化是白癜风发病机制中的必要因素。我们已经证明，HTIN产物H_4bip自动氧化（二氢纤维素（H_2PTR），二羟基毒素和翼状胬肉）占主导地位（二氢替肽（H_2bip）和生物型）。结果表明，紫外线（UV）辐射加速自氧化，而H_4BIP的氧化降解产物充当光敏剂。 H_4bip的光敏氧化可以有助于白癜风的发病机制。 H_4bip从自氧化中的紫外光氧化的主要区别特征是形成二氢醇（H_2PTR）_2和二氢纤维（H_2BIP）_2二聚体的形成。在这里，我们报道了使用氙灯和UV可调谐激光器作为UV辐射源的辐射波长和强度的依赖性。结果表明，具有激光的UV照射比与氙灯更有效。确定通过通过308-312nm的波长照射H_4bip溶液来形成最大数量的二聚体。在UVB窄带vitiligo光疗法的背景下讨论获得的数据。

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