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首页> 外文会议>World Textile Conference >New Approach Towards m-PEG Grafting Onto Commercially Available Nylon 6 To Resist Bacterial Adhesion On Surface
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New Approach Towards m-PEG Grafting Onto Commercially Available Nylon 6 To Resist Bacterial Adhesion On Surface

机译：M-PEG接枝到市售尼龙6的新方法，以抵抗表面上的细菌粘附

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Biofilm formation, caused particularly by pathogenic bacteria like methicillin-resistant Staphylococcus aureus (MRSA) on medical devices, is imposing threat to public health. There is thus an ever growing demand for designing materials that are both cytocompatible and resistant to biofilm formation as well as bacterial infections. Surface functionalized polyamides, such as Nylon 6, are widely used as biomaterial due to its strength, flexibility, toughness and cytocompatibility. The undertaken study is focused on the surface functionalization of Nylon 6 by reducing the surface with borane-tetrahydrofuran complex (BH3-THF), followed by grafting with poly(ethylene glycol) methyl ether tosylate (mPEG-OTs) via a novel lithiation approach. The modified Nylon 6 surfaces were characterized by various techniques such as water contact angle (WCA) analysis, atomic force microscopy (AFM), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) to confirm the modification of Nylon 6 surface. Evaluation of bacterial adhesion on the pure and modified surface against biofilm active pathogenic bacterial strain: Staphylococcus aureus (S.A.) CCM 3953 was accomplished. The functionalized Nylon 6 surfaces showed significant resistance towards bacterial adhesion compared to pure Nylon 6.
机译：生物膜的形成，由病原性细菌等在医疗装置上的耐甲氧西林金黄色葡萄球菌（MRSA）引起的特别是对公众健康的威胁气势。因此存在用于设计都是细胞相容性和生物膜的形成以及细菌感染性材料的不断增长的需求。表面官能化的聚酰胺，如尼龙6，被广泛用作生物材料由于其强度，柔软性，韧性和细胞相容性。所述进行研究是通过减少与硼烷 - 四氢呋喃复合物（BH 3·THF）的表面集中在尼龙6的表面官能化，随后通过一种新颖的锂化的方法用聚（乙二醇）甲基醚甲苯磺酸盐（MPEG-OTS）接枝。的改性尼龙6的表面进行了表征通过各种技术，例如水接触角（WCA）分析，原子力显微镜（AFM），扫描电子显微镜（SEM）和傅里叶变换红外光谱（FTIR）来确认尼龙6表面的改性。针对生物膜活性的致病细菌菌株的纯和改性的表面上的细菌粘附的评价为：金黄色葡萄球菌（S.A.）CCM 3953被完成。相比纯尼龙6所述的官能化的尼龙6表面朝向显示细菌粘附显著电阻。

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