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首页> 外文会议>Brazilian Congress on Biomedical Engineering >Evaluation of Rate of Muscular Force Development in Type 2 Diabetic Individuals with and without Diabetic Peripheral Neuropathy
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Evaluation of Rate of Muscular Force Development in Type 2 Diabetic Individuals with and without Diabetic Peripheral Neuropathy

机译：2型糖尿病患者肌肉力发育率的评价，患有糖尿病外周神经病变的2型糖尿病个体

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Diabetic peripheral neuropathy (DPN) has been associated with motor dysfunctions, such as reduction in the maximum force of ankle dorsiflexion and muscle atrophy in the lower limbs. These changes contribute to functional limitations, such as changes in gait. The rate of muscular force development (RFD) is derived from the force-time curve obtained during a maximal voluntary isometric contraction (MVIC), performed in a short period of time. RFD seems to be better related to gait changes and neuromuscular dysfunctions than the MVIC. Therefore, the purpose of this study was to evaluate alterations in the RFD in type 2 diabetic individuals with and without DPN. Twenty-two adults participated in the study, divided in three groups: control (n = 8), diabetic without DPN (n = 8) and diabetic with DPN (n = 7). The participants performed three MVIC of the ankle dorsiflexion. To the analysis of the force-time curve, it was selected the highest of the three MVICs obtained. The force-time curve was normalized by the peak value of MVIC. RFD was derived as the slope of the force-time normalized curve over the 0-50% and 0-100% force ranges of the MVIC. The area and time to achieve this ranges were also calculated. The MVIC force was significantly lower (p < 0.05) for the group with DPN (187.78 ±71.70 N) when compared to the control group (275.77 ± 88.13 N). The RFD_((0-50%)) was significantly lower (p < 0.05) for the group with DPN (115 ± 44% MVIC/s) in relation to the control group (233 ± 102% MVIC/s). The RFP_((0_100%)) was significantly lower (p < 0.05) for the groups without DPN (64 ± 22% MVIC/s) and with DPN (61 ± 24% MVIC/s) when compared to the control group (114 ± 45% MVIC/s). We conclude that these alterations may be related to muscle fiber atrophy, and loss of the motor unit caused by diabetes mellitus and DPN.
机译：糖尿病外周神经病变（DPN）已经与电动机功能障碍有关，例如降低下肢踝关节背屈和肌肉萎缩的最大力。这些变化有助于功能限制，例如步态的变化。肌肉力发育（RFD）的速率来自于在短时间内进行的最大自愿等距收缩（MVIC）期间获得的力 - 时间曲线。 RFD似乎与Gait的变化和神经肌肉功能障碍似乎比MVIC更好。因此，本研究的目的是评估具有和不含DPN的2型糖尿病个体中RFD中的改变。二十二名成年人参加了该研究，分三组：对照（n = 8），糖尿病没有DPN（n = 8）和DPN（n = 7）的糖尿病。参与者进行了三个踝脚折的脚踝。为了分析力时间曲线，选择了所获得的三种MVIC的最高。通过MVIC的峰值标准化力 - 时间曲线。 RFD被推出为MVIC的0-50％和0-100％力范围的力 - 时间归一化曲线的斜率。还计算了实现这一范围的地区和时间。与对照组（275.77±88.13 n）相比，MVIC部队对于具有DPN（187.78±71.70n）的组显着降低（P <0.05）。对于对照组，RFD _（（0-50％））对于具有DPN（115±44％MVIC / S）的组显着降低（P <0.05）（233±102％MVIC / s）。与对照组相比，RFP _（（0_100％））对于没有DPN（64±22％MVIC / S）和DPN（61±24％MVIC / s）的组（114）（114 ±45％mvic / s）。我们得出结论，这些改变可能与肌肉纤维萎缩有关，并且由糖尿病和DPN引起的运动单元的丧失。

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