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首页> 外文会议>International Conference on the Development of Biomedical Engineering in Vietnam >Microfluidic Impedance Biosensors for Monitoring a Single and Multiple Cancer Cells in Anticancer Drug Treatments
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Microfluidic Impedance Biosensors for Monitoring a Single and Multiple Cancer Cells in Anticancer Drug Treatments

机译：用于监测抗癌药物治疗中单个和多种癌细胞的微流体阻抗生物传感器

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摘要

In this work, we present a novel microfluidic impedance biosensor chip for trapping both a single and multiple cancer cells and monitoring their response to the anticancer drag treatment. By designing different sizes of working microelectrodes together with the V-shaped cell capture structures, a single or multiple cells are trapped on the microelectrodes surfaces. In addition, by utilizing the passive pumping method, cells can be trapped and positioned inside the microchannels without the need of using the outer micro pump or syringe. The impedance change induced by the response of cells to the anticancer drug Cisplatin treatment was successfully recorded. The proposed biosensor chip has a great potential for applications in cancer cell research, drug screening, and quantification of cancer cells from various tumor stages. The results of this study open potential research collaborations about development of cost-effective devices and lab-on-chips for early disease detection, studies of cancerous cells arid their response to anti-cancer drugs to optimize cancer treatments, characterisation of mechanical properties of cells, new drug delivery mechanisms, and micro and nano manufacturing.
机译：在这项工作中，我们提出了一种新型微流体阻抗生物传感器芯片，用于捕获单一和多种癌细胞和对抗癌拖曳治疗的反应。通过将不同尺寸的工作微电极与V形电池捕获结构一起设计，单个或多个单元被捕获在微电极表面上。另外，通过利用被动泵送方法，可以在微通道内捕获并定位在微通道内的情况下，而不需要使用外部微泵或注射器。成功记录了细胞对抗癌药物顺铂治疗的响应引起的阻抗变化。该拟议的生物传感器芯片具有巨大的癌细胞研究，药物筛选和来自各种肿瘤阶段的癌细胞的定量的潜力。这项研究结果开放了关于开发成本效益的设备和早期疾病检测的实验室芯片的潜在研究合作，对癌细胞的研究干燥他们对抗癌药物的反应来优化癌症治疗，表征细胞的力学性质，新药递送机构和微型和纳米制造。

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