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Microstructure Characterization of Cancellous Bone Based on-Ultrasonic C-Scan'Imaging

机译:基于超声波C扫描的松质骨的微观结构特征

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Ultrasonic backscatter signals can reflect the microstructural information of cancellous bone. The goal of this study is to characterize the microstructure of cancellous bone in the mesoscale and estimate trabecular thickness (Tb.Th), trabecular bone separation (Tb.Sp), bone volume fraction (BV/TV) and structure model index (SMI) based on ultrasonic C-scan imaging. Nine cuboid cancellous bone samples were prepared in this experiment. The bone samples were scanned using an ultrasound C-scan equipment with a 30 MHz focused transducer. The -6 dB lateral resolution of the transducer was 0.157 mm. The scanning interval was 0.05 mm. The scanning region of interest was 10x10 mm in the center of the cancellous bone sample. The cancellous bone images were obtained based on time of flight (TOF) and amplitude (AMP). The trabecular microstructure information was analyzed based on the ultrasonic C-scan images and compared with those obtained by μ-CT. The microstructure of trabecular bone can be clearly seen in the TOF and AMP images. The microstructure estimated based on the ultrasonic images was similar to the u-CT provided results. The estimated parameters including Tb.Th, Tb.Sp, BV/TV and SMI had an average estimation error of 21, 22, 17 and 12% with a moderate correlation to the u-CT measured results. The results demonstrated that ultrasonic C-scan imaging can be used to evaluate cancellous bone's microstructure.
机译:超声波反向散射信号可以反映松质骨的微观结构信息。本研究的目的是表征中尺度和估计的小梁厚度(TB.TH),小梁骨分离(TB.SP),骨体积分数(BV / TV)和结构模型指数(SMI)中的松质骨的微观结构基于超声C扫描成像。在该实验中制备了九间立方体松质骨样品。使用具有30MHz聚焦换能器的超声C扫描设备扫描骨骼样品。换能器的-6 dB横向分辨率为0.157mm。扫描间隔为0.05mm。感兴趣的扫描区域在松质骨样品的中心位于10x10mm。基于飞行时间(TOF)和幅度(AMP)获得松质骨图像。基于超声C扫描图像分析了短边谱微结构信息,并与通过μ-CT获得的那些相比。可以在TOF和AMP图像中清楚地看到小梁骨的微观结构。基于超声图像估计的微结构类似于U-CT提供的结果。估计的参数包括TB.Th,TB.SP,BV / TV和SMI的平均估计误差为21,22,17和12%,其与U-CT测量结果中等相关。结果表明,超声波C扫描成像可用于评估松质骨骼的微观结构。

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