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首页> 外文会议>Mediterranean Conference on Medical and Biological Engineering and Computing >Hybrid Integral Asymmetric Cellulose Acetate/Silicon Dioxide Ultrafiltration Membranes for Uremic Blood Purification
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Hybrid Integral Asymmetric Cellulose Acetate/Silicon Dioxide Ultrafiltration Membranes for Uremic Blood Purification

机译：杂种积分不对称纤维素乙酸盐/二氧化硅超滤膜用于尿毒血液净化

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摘要

Monophasic hybrid cellulose acetate/silica (CASiO2) integrally skinned membranes with silica contents between 5-18 wt.% were synthetized by an innovative method which combines the phase inversion and sol-gel techniques. The morphological and topographical characterization was performed by scanning electron microscopy (SEM) and atomic force microscopy (AFM). Permeation experiments were performed to determine the hydraulic permeability and rejection coefficients to reference solutes pertaining to the metabolic functions of the kidney. SEM confirmed asymmetric membrane cross-section structures and AFM showed that the introduction of silica reduced the submicron surface roughness at least 3 times compared to the pure CA membrane reaching a roughness mean value below 2.5 nm. Permeation studies show that the integration of silica into CA membranes increased hydraulic permeability of the hybrid CASiO2 membranes by a factor of ~2 and that all of the hybrid membranes fully permeate urea and totally reject albumin. In terms of hemocompatibility, all of the CASiO2 membranes are non-hemolytic, low thrombogenic and do note promote the highest stages of platelet activation.
机译：单次杂交纤维素乙酸纤维素/二氧化硅（CasiO2）通过组合相倒置和溶胶 - 凝胶技术的创新方法合成了5-18重量％的二氧化硅含量的整体剥皮膜。通过扫描电子显微镜（SEM）和原子力显微镜（AFM）进行形态和地形表征。进行渗透实验以确定液压渗透率和排斥系数，以参考肾脏的代谢功能。 SEM确认的不对称膜横截面结构和AFM表明，与纯Ca膜相比，二氧化硅引入至少3次达到粗糙度平均值低于2.5nm的粗糙度。渗透性研究表明，二氧化硅将二氧化硅与Ca膜的整合增加了杂交CasiO2膜的液压渗透率〜2的因子，并且所有杂种膜完全渗透尿素和完全拒绝白蛋白。就血液相容性而言，所有Casio2膜都是非溶血性的，低血栓形成，并且注意促进血小板活化的最高阶段。

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