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首页> 外文会议>Conference on Biophotonics and Immune Responses >Laser tumor thermotherapy: Is there a clinically relevant effect on the immune system?
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Laser tumor thermotherapy: Is there a clinically relevant effect on the immune system?

机译：激光肿瘤热疗：是否存在对免疫系统有关的临床相关影响？

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Laser thermotherapy is interesting from an immunological point of view since it can reduce tumor volume without causing immunosuppression at the same time as it may induce and/or enhance tumor immunity. In a rat liver tumor model, we have demonstrated that laser thermotherapy 1) is superior to surgical resection, 2) gives a strong rejection immunity associated with an immune cellular response of tumor-infiltrating macrophages and CD8 lymphocytes, 3) results in pronounced suppression of the growth of a simultaneous untreated tumor (distant bystander effect), 4) produces an increased anti-tumor lymphocyte proliferative response in tumor-draining and systemic lymph nodes and spleen, and 5) results in increased HSP70 immunoreactivity in tumors and tumor-infiltrating macrophages. Thus, the evidence for a laser-induced immunologic effect in tumor-bearing rats is strong. Some observations suggest that laser thermotherapy may be used for inducing favorable immunologic effects also in patients. Thus, we have shown a laser-induced bystander effect in a patient with malignant melanoma. In patients with breast cancer we have shown that laser thermotherapy induces intratumoral infiltration of immunocompetent cells like CD68 macrophages and CD8 lymphocytes. Laser thermotherapy is likely to be beneficial mainly when tumor burden is small, that is, when treatment is performed with curative intent, either with laser alone or together with surgical resection. For optimal effect, it appears likely that thermotherapy should be combined with other therapies. Most likely, a clinically meaningful effect can only be proven in prospective randomized studies comparing thermotherapy with other methods, particularly surgical resection.
机译：激光热处理来自免疫学的观点，因为它可以减少肿瘤体积而不会在可能诱导和/或增强肿瘤免疫的同时引起免疫抑制。在大鼠肝脏肿瘤模型中，我们已经证明激光热疗1）优于手术切除，2）给出了与肿瘤浸润巨噬细胞和CD8淋巴细胞的免疫细胞反应相关的强抑制免疫力，3）导致明显的抑制同时未处理的肿瘤（远处旁观者效应）的生长产生肿瘤排水和全身淋巴结和脾脏的增加的抗肿瘤淋巴细胞增殖反应，5）导致肿瘤和肿瘤浸润性巨噬细胞的HSP70免疫反应增加。因此，在携带肿瘤大鼠中激光诱导的免疫效应的证据强。一些观察结果表明激光热疗可用于患者也可用于诱导有利的免疫效应。因此，我们在恶性黑素瘤的患者中显示了激光诱导的旁观者效应。在乳腺癌患者中，我们表明激光热疗诱导免疫活性细胞的肿瘤内渗透，如CD68巨噬细胞和CD8淋巴细胞。激光热疗可能主要是有益的，主要是肿瘤负担较小，即当治疗用治疗意图进行时，用激光单独或与手术切除一起进行。为了最佳效果，似乎可能与其他疗法相结合。最有可能的是，临床上有意义的效果只能在预期随机研究中被证明，比较其他方法，特别是手术切除的热疗。

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