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首页> 外文会议>Asian BioCeramicSymposium >Diametral Tensile Strength Evaluation of Carbonate Apatite Cement Reinforced by Genipin Cross-Linked Gelatin
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Diametral Tensile Strength Evaluation of Carbonate Apatite Cement Reinforced by Genipin Cross-Linked Gelatin

机译：Genipin交联明胶增强碳酸盐水泥的径向拉伸强度评价

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Carbonate apatite (CO_3Ap) is one of the most widely studied bioceramic material for its use as bone cement. It is well-known that CO_3Ap cement has good osteoconductivity which makes this cement could be replaced by bone. However, the mechanical strength of CO_3Ap cement is still low. This low mechanical strength is estimated due to the high porosity and absence of organic components. The aim of this study is to improve the mechanical strength of the CO_3Ap cement reinforced by gelatin as an organic component with genipin as a cross-linking agent (Gelapin). The powder phase of vaterite and DCPA at weight ratio 40:60 were mixed with 0.2 mol/L Na_2HPO_4, 5% (w/v) gelatin, and 20% (v/v) genipin using 0.5 liquid to powder (L/P) ratio. The liquid phase ratios of Na_2HPO_4 and Gelapin were 50:50, 70:30, and 90:10. For control group, Gelapin was not mixed into the liquid. Diametral tensile strength was improving and statistically significant (p<0.05) on set cement with 50:50 liquid ratio, the average value was 6.02 ± 0.14 MPa whereas the average value of the control group was only 3.10 ± 0.15 MPa. For this instance, gelatin serves a polymer matrix so the carbonate apatite crystallites could be well distributed within it which then gives more flexibility and resistance for the cement. On the other hand, genipin was also successfully cross-linked the gelatin. This study showed that by reinforcing CO_3Ap cement using genipin cross-linked gelatin might be a good candidate for a bone substitute material.
机译：碳酸盐磷酸盐（CO_3AP）是最广泛研究的生物陶瓷材料之一，用于其用作骨水泥。众所周知，CO_3AP水泥具有良好的骨导电性，使得这种水泥可以被骨代替。然而，CO_3AP水泥的机械​​强度仍然很低。由于具有高孔隙率和有机组分的缺乏，估计这种低机械强度。本研究的目的是提高由明胶加固的CO_3AP水泥的机械​​强度作为具有Genipin作为交联剂（Gelapin）的有机组分。 Vaterite的粉末相和重量比40:60的DCPA与0.2mol / L Na_2HPO_4,5％（w / v）明胶和20％（v / v）Genipin混合到粉末（L / P）比率。 Na_2HPO_4和Gelapin的液相比为50:50,70:30和90:10。对于对照组，Gelapin未混合到液体中。径向拉伸强度改善和统计学意义（P <0.05）在固定水泥上含有50:50液体比，平均值为6.02±0.14MPa，而对照组的平均值仅为3.10±0.15MPa。对于这种情况，明胶用作聚合物基质，因此碳酸盐磷灰石微晶可以很好地分布在其中，然后给水泥提供更多的柔韧性和抗性。另一方面，Genipin也成功地交联了明胶。该研究表明，通过使用Genipin交联的明胶增强CO_3AP水泥可能是骨替代材料的良好候选者。

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