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首页> 外文会议>Asian BioCeramicSymposium >Preparation and Characterization of Terpenoid-Encapsulated PLGA Microparticles and its Antibacterial Activity Against Enterococcus faecalis
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Preparation and Characterization of Terpenoid-Encapsulated PLGA Microparticles and its Antibacterial Activity Against Enterococcus faecalis

机译：Terpenoid包封的PLGA微粒的制备与表征及其对肠球菌粪便的抗菌活性

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Exploration of natural compound for the treatment of dental-related problems are gaining of interest for enhancing therapeutic efficacy of the drugs delivery system. In this study, we have prepared terpenoid, which have been isolated from Myrmecodia pendens Merr & Perry from Papua Island, Indonesia, to be encapsulated in Polylactic-co-glycolic acid (PLGA), as the most widely used biodegradable polymer for biomedical applications, through one step single-emulsion method followed by subsequent coating by poly (vinyl alcohol) (PVA). The resultant of terpenoid-loaded PLGA microparticles were characterized systematically through scanning electron microscope and Fourier-transform infrared spectroscopy. In vitro drug release test was evaluated through dialysis method. Antibacterial test was conducted against Enterococcus faecalis as a model for persistent bacteria that causes root canal infections. The results showed that terpenoid-loaded PLGA microparticles were developed in spherical morphology with an average particle size of around 1-2um. Terpenoid released from PLGA compartment at pH 6.5 and temperature of 37oC through a controlled-release profile mechanism with enhanced prolonged release. The bacterial assay result showed that terpenoid-loaded PLGA microparticles could reduce Enterococcus faecalis, effectively. Eventually, these result show that terpenoid-loaded PLGA microparticles as unique natural product-based extract could be developed as a potential naturally-based drug for dental-related diseases applications.
机译：对于牙齿相关问题的处理的天然化合物的探索是为提高药物输送系统的治疗效果获得的利益。在这项研究中，我们已经准备萜类化合物，其已经从Myrmecodia分离决案件MERR＆佩里从巴布亚岛，印度尼西亚，在聚乳酸 - 共 - 乙醇酸（PLGA）被封装，作为用于生物医学应用最广泛使用的生物可降解聚合物，通过一个步骤单乳化法，随后接着通过涂覆聚（乙烯醇）（PVA）。萜类加载的PLGA微粒的所得物通过扫描电子显微镜和傅立叶变换红外光谱仪系统，其特征在于。体外药物释放试验通过透析法进行评价。抗菌试验抗粪肠球菌进行作为用于持久性细菌的模型使根管感染。结果表明，萜类加载的PLGA微粒在球形形态开发了围绕1-2um的平均颗粒尺寸。通过具有增强的延长释放的受控释放曲线从机构隔室PLGA萜释放在pH 6.5和37℃的温度。细菌试验结果表明，萜类加载PLGA微粒可有效降低粪肠球菌。最终，这些结果表明，萜类加载PLGA微粒作为独特的天然产品为基础的提取物可被开发为一个基于天然物质的潜在药物牙科相关疾病的应用。

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