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Microlocalization of Photofrin in neoplastic lesions

机译：肿瘤病变中的Photofrin的微钙化

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Three tumor models were used to study the microlocalization of two photosensitizers, Photofrin and TPPS$-4$/ (mesotetra$LB@p-sulphophenyl$RB@porphyne). The three tumor types employed were subcutaneously and intramuscularly grown murine Lewis lung carcinoma, and lung micrometastases, grown on the same animal. The objective of the study was to determine whether these photosensitizers localize differently in these three tumor types. Common to all the tumors was the observation that no substantial photosensitizer fluorescence could be found in the tumor parenchyma. With Photofrin, most of the drug fluorescence was found in the periphery of the tumors, especially around blood vessels and possibly in some macrophages. On the other hand with TPPS$-4$/, most of the fluorescence was seen in the basement membrane of blood vessels and airways. The photosensitizer TPPS$-4$/ may therefore accumulate less specifically in tumor microenvironment than Photofrin. Both photosensitizers were also found to localize in necrotic areas.
机译：使用三种肿瘤模型研究两个光敏剂的微生物化，Photofrin和TPPS $ -4 $ /（Mesotettra $ lb @ p-sulphophynyl $ rb @ porphyne）。使用的三种肿瘤类型被皮下和肌内生长的小鼠肺癌和肺部微转移，在同一动物中生长。该研究的目的是确定这些光敏剂是否在这三种肿瘤类型中不同地定位。所有肿瘤的常见是观察结果，即在肿瘤实质中没有发现基本的光敏剂荧光。用Photofrin，大多数药物荧光在肿瘤的周边中发现，尤其是血管周围并且可能在一些巨噬细胞中。另一方面，具有TPPS $ -4 $ /，大多数荧光在血管和呼吸道的基底膜中看到。因此，光敏剂TPPS $ -4 $ /可以在肿瘤微环境中小于photofrin积累。也发现两种光敏剂都在坏死区域定位。

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