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Microlocalization of Photofrin in neoplastic lesions

机译：Photofrin在肿瘤病变中的微定位

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Abstract: Three tumor models were used to study the microlocalization of two photosensitizers, Photofrin and TPPS$-4$/ (mesotetra$LB@p-sulphophenyl$RB@porphyne). The three tumor types employed were subcutaneously and intramuscularly grown murine Lewis lung carcinoma, and lung micrometastases, grown on the same animal. The objective of the study was to determine whether these photosensitizers localize differently in these three tumor types. Common to all the tumors was the observation that no substantial photosensitizer fluorescence could be found in the tumor parenchyma. With Photofrin, most of the drug fluorescence was found in the periphery of the tumors, especially around blood vessels and possibly in some macrophages. On the other hand with TPPS$-4$/, most of the fluorescence was seen in the basement membrane of blood vessels and airways. The photosensitizer TPPS$-4$/ may therefore accumulate less specifically in tumor microenvironment than Photofrin. Both photosensitizers were also found to localize in necrotic areas.!
机译：摘要：使用三种肿瘤模型研究了两种光敏剂Photofrin和TPPS $ -4 $ /（mesotetra $ LB @ p-sulphophenyl $ RB @ porphyne）的微定位。所使用的三种肿瘤类型是皮下和肌内生长的鼠刘易斯肺癌，以及在同一只动物上生长的肺微转移。该研究的目的是确定这些光敏剂在这三种肿瘤类型中的定位是否不同。所有肿瘤的共同点是在肿瘤实质中未发现大量光敏剂荧光。使用Photofrin，大多数药物荧光都在肿瘤的周围，尤其是在血管周围，甚至在某些巨噬细胞中。另一方面，对于TPPS $ -4 $ /，大多数荧光可见于血管和气道的基底膜中。因此，光敏剂TPPS $ -4 $ /在肿瘤微环境中的积累可能比Photofrin少。还发现两种光敏剂都位于坏死区域。

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