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Comparative evaluation of photodynamic activity of several HpD and different samples of sulphonated aluminum phthalocyanine

机译:几种HPD的光动力活性和不同样品对磺化铝酞菁的不同样品的比较评价

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Three samples of sulphonated aluminum phthalocyanine with predominance of different sulphonated degree (AlPcSn) were investigated in vivo in comparison with different commercial samples of HpD. The criterium of primary biological assessment of photodynamic activity was the field of necrosis spot upon the liver tissue of mice under the same parameters of influence combination. The preliminary experimental and morphological study of antitumor activity demonstrates different mechanisms of photodynamic activity when we use for PDT more effective di- and trisulphonated phthalocyanine Al and most effective from HpD -Photofrin II.
机译:与HPD的不同商业样品相比,体内研究了三种磺化铝酞菁的磺化铝酞菁,其具有不同的磺化程度(ALPCSN)。光动力学活性的原发性生物学评估标准是在相同的影响组合参数下小鼠肝组织的坏死斑点。抗肿瘤活性的初步实验和形态学研究表明,当我们用于PDT更有效的二苯胺和三硫氰酸酯,并且来自HPD -PHOPOFRIN II最有效的,抗动力学活性的不同机制。

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