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Plaque localization enhanced by exogenous chromophore /spl beta/-carotene

机译:外源发色团/SPRβ/ -Carotene增强斑块定位

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/spl beta/-carotene, an antioxidant which may alter the course of atherosclerosis by preventing the oxidation of LDL, has potential therapeutic benefit in humans. Studies are outlined which illustrate that yellow /spl beta/-carotene is only present in atherosclerotic plaque but not in the normal artery. By absorbing 450-500 nm laser radiation, /spl beta/-carotene confers preferential absorption to the plaque, making both selective ablation therapy and selective fluorescence detection possible. Furthermore, yellow coloration of plaques can also improve plaque visualization by angioscopy. Recently pathological studies suggest that vulnerable plaques may have thin fibrous caps overlying cholesterol-rich lipid cores. Therefore, yellow color variation in plaque visualization by angioscopy may be related to the cap thickness which is potentially important for predicting plaque disruption and thrombus formation.
机译:/SPRβ/ -Carotene,可以通过防止LDL氧化来改变动脉粥样硬化过程的抗氧化剂,对人类具有潜在的治疗益处。概述了研究表明,黄色/SPRβ/ -Carotene仅存在于动脉粥样硬化斑块中,但不存在于正常动脉中。通过吸收450-500nm激光辐射,/SPRβ/ -Carotene赋予斑块的优先吸收,使得选择性消融治疗和选择性荧光检测可能。此外,斑块的黄色着色还可以通过血管镜检查来改善斑块可视化。最近的病理学研究表明,脆弱的斑块可能具有含胆固醇的脂质核心覆盖的薄纤维帽。因此,通过血管镜检查的斑块可视化的黄色变化可能与帽厚度有关,这对于预测斑块破坏和血栓形成可能是重要的。

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