Proteins and nucleic acids are two of the most important macromolecules in living organisms. Phosphorus plays a significant role in the structure or functions of these two classes of molecules. For example, phosphodiester is the backbone of DNA and RNA, and many proteins' activity were regulated through phosphorylation and de-phosphorylation on their side chains [1]. In the last decade our group had studied the characteristics of N-dialklphosphoryl amino acids, which embodied the basic archtiecture of phosphodiester and phosphoproteins in one molecule. It was found that many bio-mimic reactions, such as self-catalysis to yield peptides in organic solvents or even in aqueous solution [2,3], ester exchange reactions on phosphorus in alcoholic media [4,5] could occur on the dialkylphosphoryl amino acids.
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