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Folding intermediate of beta -lactoglobulin with non-native alpha -helical conformation

机译：具有非天然α的β-裂藻蛋白的折叠中间体 - Helical兼容

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Protein folding is a process in which a polypeptide chain attains a unique native structure that is determined by its amino acid sequence. Several mechanisms have been proposed to explain the efficient folding process of globular proteins. In particular, a sequential and hierarchical folding mechanism with a molten globule intermediate has been popular [1]. In contrast, a nucleation/condensation model of protein folding has been recently evaluated, in which the rate-limiting step is the formaiton of a nucleus [2]. In both models, it is generally considered that the intermediate conformational states assume the native-like substructures (hierarchical mechanism of folding).

机译：蛋白质折叠是一种过程，其中多肽链达到独特的天然结构，其由其氨基酸序列测定。已经提出了几种机制来解释球状蛋白的有效折叠过程。特别地，具有熔融小球中间体的顺序和分层折叠机构已经受欢迎[1]。相反，最近已经评估了蛋白质折叠的成核/缩合模型，其中速率限制步骤是核[2]的形式分子。在这两种模型中，通常认为中间构象状态呈现类似地形子结构（折叠的分层机制）。

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《Chinese peptide symposium》|1998年||共2页
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Y.Goto; D.Hamada; S.Segawa;
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中图分类抗体蛋白与干扰素蛋白;
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专利

1. Comparison of the conformational stability of the non-native alpha-helical intermediate of thiol-modified beta-lactoglobulin upon interaction with sodium n-alkyl sulfates at two different pH [J] . Chamani J Journal of Colloid and Interface Science . 2006,第2期

机译：硫醇修饰的β-乳球蛋白的非天然α-螺旋中间体在两种不同pH下与正烷基硫酸钠反应时的构象稳定性比较
2. Highly Collapsed Conformation of the Initial Folding Intermediates of beta-Lactoglobulin with Non-Native alpha-Helix [J] . Konuma Tsuyoshi, Sakurai Kazumasa, Yagi Masanori, Journal of Molecular Biology . 2015,第19期

机译：β-乳球蛋白与非天然α-螺旋的初始折叠中间体的高度折叠构象
3. Non-Native alpha-Helices in the Initial Folding Intermediate Facilitate the Ordered Assembly of the beta-Barrel in beta-Lactoglobulin [J] . Sakurai Kazumasa, Yagi Masanori, Konuma Tsuyoshi, Biochemistry . 2017,第36期

机译：在初始折叠中间体中的非本机α-螺旋促进β-乳酰叶蛋白的β-筒的有序组装
4. Folding intermediate of beta -lactoglobulin with non-native alpha -helical conformation [C] . Y.Goto, D.Hamada, S.Segawa Chinese peptide symposium . 1998

机译：具有非天然α的β-裂藻蛋白的折叠中间体 - Helical兼容
5. Part I: Stucture and dynamics of beta-amyloid fibrils. Part II: Design of Taxol (Paclitaxel) analogs and predictive models; design of measles virus inhibitors; conformational analysis of alpha-helical mimics. [D] . Lakdawala, Ami Sailesh. 2004

机译：第一部分：β-淀粉样蛋白原纤维的结构和动力学。第二部分：紫杉醇（紫杉醇）类似物和预测模型的设计；麻疹病毒抑制剂的设计； α-螺旋模拟物的构象分析。
6. What is the role of non-native intermediates of β-lactoglobulin in protein folding? [O] . George Chikenji, Macoto Kikuchi 2000

机译：β-乳球蛋白非天然中间体的作用是什么在蛋白质折叠中？
7. 3P062 Effect of non-native α-helix in the early intermediate on folding kinetics of equine β-lactoglobulin(01C. Protein: Property,Poster) [O] . Takahiro Okabe, Toshiaki Miyajima, Hideaki Ohtomo, 2013

机译：3P062非天然α-螺旋在β-乳酰蛋白折叠动力学早期中间中间体的影响（01℃。蛋白质：财产，海报）

Folding intermediate of beta -lactoglobulin with non-native alpha -helical conformation

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