Nitroficated handle structure between peptide chain and resin carrier was conventionally used as photolabile linkage in solid-phase peptide synthesis before [1,2]. However, it has never been commonly used like other handle structures, such as -CH_2(C_6H_4)-, -CH_2 (C_6H_4)-OCH_2(C_6H_4)-, MBHA, PAM, ... etc., just because of the apparatus restriction in photolytic cleaving experiment. The introduction of -NO_2 group into phenylene ring of handle structure can dramatically reduce the electron density from the carbonyl group at benzyl ester moiety. As a result, the ester bonds in nitro-resin should be much more acid resistant than the same bons in non-nitroficated resin. Peptide should be released more easily from nitro-resin than from other resins by saponification.
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