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Amphipathic helical potency and its relationship to the biological activity of synthetic calcitonin derivatives

机译：两性疗法循环效力及其与合成降钙素衍生物生物活性的关系

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Three structural regions: a seven-residue cyclic segment at the N-terminus formed by a disulfide bond between cysteines at positions 1 and 7, an amphipathic alpha -helix from residue 8 tothe helix-breaking proline at position 23, and a hydrophilic random coil segment from residue 23 to the C-terminal proline amide may be important in the biological activity of calcitonin [1]. Four salmon calcitonin (sCT) analogues were designe,d synthesized and their conformational properties were studied by Fourier-transform infrared (FTIR) spectroscopy and circular dichroism (CD).

机译：三个结构区域：通过在位置1和7的半胱氨酸之间的二硫键形成的N-末端的七残基循环区段，来自残留物8的两亲α-helix在第23位，螺旋破裂脯氨酸和亲水性无规管将残余物23与C-末端脯氨酸酰胺的链段在降钙素中的生物活性中可能是重要的[1]。四种鲑鱼降钙素（SCT）类似物是设计，D合成的D合成，并通过傅里叶变换红外（FTIR）光谱和圆形二色性（CD）研究了它们的构象性能。

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《Chinese peptide symposium》|1998年||共2页
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Hou-Li Jiang; Bin Yang; Bing-Yu LIu; Ye-Mei Fan; Shi-Jie Shen; Zhen-Kai Ding;
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中图分类抗体蛋白与干扰素蛋白;
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1. Non-perfectly Amphipathic alpha-Helical Structure Containing the XXYXX Sequence Improves the Biological Activity of Bovine alpha(s2)-Casein Antimicrobial Peptides [J] . Gu Liya, Sun Changbao, Chen Lijun, Journal of Agricultural and Food Chemistry . 2020,第28期

机译：含有XXYXX序列的非完美性α-螺旋结构改善了牛α的生物活性 - 粉底蛋白抗菌肽肽
2. Effects of Single Amino Acid Substitution on the Biophysical Properties and Biological Activities of an Amphipathic alpha-Helical Antibacterial Peptide Against Gram-Negative Bacteria [J] . Tan Juanjuan, Huang Jinfeng, Huang Yibing, Molecules . 2014,第8期

机译：单个氨基酸取代对两亲性α-螺旋抗菌肽对革兰氏阴性细菌的生物物理特性和生物活性的影响
3. Effects of Single Amino Acid Substitution on the Biophysical Properties and Biological Activities of an Amphipathic α-Helical Antibacterial Peptide Against Gram-Negative Bacteria [J] . Jinfeng Huang, Juanjuan Tan, Yibing Huang, Molecules . 2014,第8期

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4. Amphipathic helical potency and its relationship to the biological activity of synthetic calcitonin derivatives [C] . Hou-Li Jiang, Bin Yang, Bing-Yu LIu, Chinese peptide symposium . 1998

机译：两性疗法循环效力及其与合成降钙素衍生物生物活性的关系
5. Design, synthesis, and structure-activity relationship investigation of 3',4'-disubstituted pyranochromone derivatives with diverse biological activities [D] . Zhou, Ting 2010

机译：具有多种生物活性的3'，4'-二取代吡喃并发色酮衍生物的设计，合成及构效关系研究
6. Effects of Single Amino Acid Substitution on the Biophysical Properties and Biological Activities of an Amphipathic α-Helical Antibacterial Peptide Against Gram-Negative Bacteria [O] . Juanjuan Tan, Jinfeng Huang, Yibing Huang, 2014

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7. The hydrophobic moment of the amphipathic helix of salmon calcitonin and biological potency [O] . Richard M. EPAND, Jay K. SEYLER, Ronald C. ORLOWSKI 1986

机译：三文鱼降钙素和生物效力的两亲性螺旋的疏水力矩
8. Investigations of the Biologic Activity and Structure Function Relationships of Synthetic Polymers Which Act as Hormones, Behavior Modifiers and Thymic Immunomodulators [R] . Hunter, R. L., Check, I. J., Neill, D. B. 1988

机译：研究激素，行为调节剂和胸腺免疫调节剂的合成聚合物的生物活性和结构功能关系

Amphipathic helical potency and its relationship to the biological activity of synthetic calcitonin derivatives

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