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Development of highly potnet human parathyroid hormone analogs

机译：高潮人甲状旁腺激素类似物的发展

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There is growing evidence that human parathyroid hormone, hPTH(1-84), and its hPTH 91-34) fragment are promising therapeutic agents for treating osteoporosis in that they can stimulate production of trabecular bone in osteoporotic postmenopausal women [1]. Unlike most current therapeutic agents (i.e., estrogen, bisphosphonates, and calcitonin) which only prevent further bone loss, daily injection of hPTH (1-84) or hPTH(1-34) increases bone mass in animals and humans. The unique bone anabolic effect of hPTH has led us to search for more potent hPTH91-34) analogs.

机译：越来越多的证据表明，人甲状旁腺激素，HPTH（1-84）及其HPTH 91-34）片段是治疗骨质疏松症的治疗剂，因为它们可以刺激骨质疏松绝经后妇女的小梁骨的产生[1]。与大多数目前的治疗剂（即雌激素，双膦酸盐和降钙素）不同，这仅防止进一步的骨质损失，每日注射HPTH（1-84）或HPTH（1-34）增加动物和人类的骨质。 HPTH的独特骨骼合成效应导致我们寻找更多有效的HPTH91-34）类似物。

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《Chinese peptide symposium》|1998年||共3页
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J.Z.Dong; M.Chorev; C.Nakamoto; C.-W.Woon; B.A.Morgan; M.Rosenblatt; J.-P.Moreau;
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中图分类抗体蛋白与干扰素蛋白;
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1. PROBING THE BIMOLECULAR INTERACTIONS OF PARATHYROID HORMONE WITH THE HUMAN PARATHYROID HORMONE PARATHYROID HORMONE-RELATED PROTEIN RECEPTOR .1. DESIGN, SYNTHESIS AND CHARACTERIZATION OF PHOTOREACTIVE BENZOPHENONE-CONTAINING ANALOGS OF PARATHYROID HOR [J] . Nakamoto C, Behar V, Chin KR, Biochemistry . 1995,第33期

机译：甲状旁腺激素与人甲状旁腺激素相关的蛋白受体的双分子相互作用的研究1。甲状旁腺激素的光反应性苯甲酮类似物的设计，合成与表征
2. Expression-level dependent activation of recombinant human parathyroid hormone/parathyroid hormone-related peptide receptor: Effect of human parathyroid hormone (1-34), (1-31), and (28-48) [J] . Tonn O., Braitmaier A., Schafer W., Journal of receptor and signal transduction research . 2000,第2a3期

机译：重组人甲状旁腺激素/甲状旁腺激素相关肽受体的表达水平依赖性激活：人甲状旁腺激素（1-34），（1-31）和（28-48）的作用
3. PROBING THE BIMOLECULAR INTERACTIONS OF PARATHYROID HORMONE AND THE HUMAN PARATHYROID HORMONE PARATHYROID HORMONE-RELATED PROTEIN RECEPTOR .2. CLONING, CHARACTERIZATION, AND PHOTOAFFINITY LABELING OF THE RECOMBINANT HUMAN RECEPTOR [J] . Adams AE, Pines M, Nakamoto C, Biochemistry . 1995,第33期

机译：甲状旁腺激素与人甲状旁腺激素的相互作用甲状旁腺激素相关蛋白受体的研究2。重组人类受体的克隆，鉴定和光亲和性标签
4. Development of highly potnet human parathyroid hormone analogs [C] . J.Z.Dong, M.Chorev, C.Nakamoto, Chinese peptide symposium . 1998

机译：高潮人甲状旁腺激素类似物的发展
5. Identification of the hormone contact domains and early signaling events of the human parathyroid hormone 1 (hPTH1) receptor. [D] . Adams, Amy Erin. 2000

机译：鉴定人类甲状旁腺激素1（hPTH1）受体的激素接触域和早期信号事件。
6. Development of a highly sensitive and specific two‐site enzyme immunoassay for parathyroid hormone (1‐34): Application to pharmacokinetic study on intranasal parathyroid hormone (1‐34) in human [O] . Takeyuki Kohno, Noriaki Murasugi, Hiroki Sakurai, 1998

机译：甲状旁腺激素（1-34）的高灵敏度和特异性两点酶免疫测定方法的开发：在人鼻内甲状旁腺激素（1-34）的药代动力学研究中的应用
7. Parathyroid Hormone and Parathyroid Hormone-Related Protein Analogs as Therapies for Osteoporosis [O] . Marilyn Augustine, Mara J. Horwitz 2013

机译：甲状旁腺激素和甲状旁腺激素相关蛋白类似物作为骨质疏松症的疗法

Development of highly potnet human parathyroid hormone analogs

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