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Conformational changes of bovine pancreatic polypeptide (BPP) as it interacts with lipids

机译:牛胰多肽(BPP)与脂质相互作用的构象变化

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BPP is a linear polypeptide composed of 36 amino acid residues secreted by the pancreas [1]. Experiments in vivo demonstrated its function of treating and preventing acute pancreatiti [2]. Our research showed the effects of BPP on stabilizing the lipid bilayer structure and inhibiting the membrane fusion of liposomes [3]. After itneraction with lipids conforma-tional changes of BPP were studied by monolayer, fluorescence and FT-IR spectroscopy techniques.
机译:BPP是由胰腺分泌的36个氨基酸残基组成的线性多肽[1]。体内实验证明了其治疗和预防急性胰腺的功能[2]。我们的研究表明,BPP对脂质双层结构稳定并抑制脂质体膜融合的影响[3​​]。通过单层,荧光和FT-IR光谱技术研究了与脂质的脂质的脂质的变化变化,荧光和FT-IR光谱技术研究。

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