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Synthesis of glycopeptides with Lewis antigen or sialyl-Lewis~x antigen side chains

机译：用Lewis抗原或SiaLyl-Lewis〜X抗原侧链合成糖肽

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During the past decades it has been recognized that the glycosylation pattern of glycoproteins plays a key role in processes such as the transport of proteins through the endoplasmic reticulum or membranes, the docking of bacteria and viruses onto cells, and cell-cell recognition. Glycoproteins which carry Lewis antigen saccharide side chaisn 1 and 2 were identified as cell surface markers in cell differentiation. For example, the Lewis~x determinant 1 is formed duirng embryonic development at the 8-cell stage by alpha -1,3-fucosylation of the I determinant as a status-specific embryonic antigen (SSEA-1). Later, it is almost completely masked by fucosylation (to give the Lewis~x antigen) or sialylation [1]. Glycoproteins with sialyl Lewis~x saccharide portions 3 are important ligands of receptors located in membranes of endothelial cells (E-selectin and P-selectin), platelets (P-selectin) and leukocytes (L-selectin). The recognition of sialyl Lewis~x ligands by selectins is obviously responsible for the early steps in cell adhesion and is of increasing interest in context with inflammatory processes. It controls the recruitment of leukocytes and their subsequent invasion into the center of inflammation [2]. In contrast to sialyl Lewis~x, the occurrence of Lewis~x antigen 1 in healthy adults is restricted to certain specific regions.
机译：在过去的十年来，它已认识到糖蛋白的糖基化模式起到如蛋白质通过内质网或膜，细菌和病毒的对接到细胞，细胞 - 细胞识别的运输过程中起关键作用。携带Lewis抗原糖类侧chaisn 1和2的糖蛋白被鉴定为细胞分化的细胞表面标记。例如，路易斯〜X行列式1 duirng在8细胞期胚胎发育由I行列式作为特定状态胚抗原（SSEA-1）的阿尔法-1,3-岩藻糖基形成。后，它几乎完全被岩藻糖基掩蔽（得到路易斯〜X抗原）或唾液酸化[1]。与唾液酸基路易斯〜X糖部分3糖蛋白是位于内皮细胞（E-选择素和P-选择素），血小板（P选择素）和白细胞（L-选择）的膜受体的重要配体。唾液酸基路易斯〜X配体的由选择素识别为细胞粘附的早期步骤明显负责并且是增加在上下文中炎症过程的兴趣。它控制白细胞的募集和它们随后的侵入炎症[2]的中心。在对比唾液酸基路易斯〜X，路易斯〜X抗原1的健康成人的发生仅限于某些特定区域。

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