ICAM-1 and VCAM-1 Expression Induced by TNF-a Are Inhibited by A Glutathione Peroxidase Mimic

机译：TNF-A诱导的ICAM-1和VCAM-1表达被谷胱甘肽过氧化物酶模仿抑制

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Intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) are respectively involved in the endothelial recruitment of neutrophils and in that of lymphocytes or tumor cells, in response to specific signals. We have used the glutathione peroxidase (GPx) mimic BXT-51072 to assess the possibility that endogenous hydroperoxides play a role in the Tumor Necrosis Factor-a (TNFa)-induced expression of ICAM-1 and VCAM-1 by monolayers of human endothelial cells. The GPx mimic BXT-51072 strongly inhibits the TNFa-induced and cycloheximide-sensitive expression of ICAM-1 and VCAM-1. It also inhibits the TNFa-induced reorganization of the actin network and the associated formation of stress fibers. Actin reorganization induced by cytochalasin D treatment did not inhibit ICAM-1 expression. Our results are compatible with specific and synergistic effects of endogenous hydroperoxides on the biosynthesis and processing of cell adhesion molecules and cytoskeleton components.

机译：细胞间粘附分子-1（ICAM-1）和血管细胞粘附分子-1（VCAM-1）分别参与中性粒细胞的内皮细胞和淋巴细胞或肿瘤细胞的内皮细胞或肿瘤细胞。我们使用谷胱甘肽过氧化物酶（GPX）模拟BXT-51072来评估内源性氢过氧化物在肿瘤坏死因子-α（TNFA）中发挥作用的可能性 - 通过人类内皮细胞单层抑制ICAM-1和VCAM-1的表达。 GPX模拟BXT-51072强烈抑制ICAM-1和VCAM-1的TNFA诱导和环己酰亚胺敏感表达。它还抑制了肌动蛋白网络的TNFA诱导的重组和应力纤维的相关形成。细胞蛋白酶D治疗诱导的肌动蛋白重组不抑制ICAM-1表达。我们的结果与内源性氢过氧化物对细胞粘附分子和细胞骨架组分的生物合成和加工的具体和协同作用相容。

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《NATO Advanced Study Institute on Vascular Endothelium : Mechanisms of Cell Signaling》|1999年||共6页
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Patrizia D Alessio; Marc Moutet; Evelyne Coudrier; Sophie Darquennev; Jean Chaudiere;
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1. Protein C activation peptide inhibits the expression of ICAM-1, VCAM-1, and interleukin-8 induced by TNF-a in human dermal microvascular endothelial cells [J] . María Del Socorro Pina-Canseco, Araceli Páez-Arenas, Felipe Massó, Folia histochemica et cytobiologica . 2012,第3期

机译：蛋白C激活肽抑制人皮肤微血管内皮细胞中TNF-α诱导的ICAM-1，VCAM-1和白介素8的表达
2. Interleukin-1-induced nuclear factor kappa B activation is inhibited by overexpression of phospholipid hydroperoxide glutathione peroxidase in a human endothelial cell line. [J] . Brigelius Flohe R, Friedrichs B, Maurer S, The Biochemical Journal . 1997,第Pta1期

机译：在人内皮细胞系中过氧化磷脂氢过氧化物谷胱甘肽过氧化物酶抑制白介素-1诱导的核因子κB活化。
3. Interleukin-1-induced nuclear factor κB activation is inhibited by overexpression of phospholipid hydroperoxide glutathione peroxidase in a human endothelial cell line [J] . B?rbel FRIEDRICHS, Manfred SCHULTZ, Regina BRIGELIUS-FLOHé, The biochemical journal . 1997,第1期

机译：磷脂氢过氧化物谷胱甘肽过氧化物酶在人内皮细胞系中的过表达抑制白介素-1诱导的核因子κB活化
4. ICAM-1 and VCAM-1 Expression Induced by TNF-a Are Inhibited by A Glutathione Peroxidase Mimic [C] . Patrizia D Alessio, Marc Moutet, Evelyne Coudrier, NATO Advanced Study Institute on Vascular Endothelium : Mechanisms of Cell Signaling . 1999

机译：TNF-A诱导的ICAM-1和VCAM-1表达被谷胱甘肽过氧化物酶模仿抑制
5. Expression and regulation of ICAM-1 and VCAM-1 in streptococcal-cell-wall-induced hepatic granuloma [D] . Xie, Lei. 1996

机译：ICAM-1和VCAM-1在链球菌细胞壁诱导的肝肉芽肿中的表达和调控
6. Interleukin-1-induced nuclear factor kappa B activation is inhibited by overexpression of phospholipid hydroperoxide glutathione peroxidase in a human endothelial cell line. [O] . R Brigelius-Flohé, B Friedrichs, S Maurer, 1997

机译：在人内皮细胞系中过氧化磷脂氢过氧化物谷胱甘肽过氧化物酶抑制白介素-1诱导的核因子κB活化。
7. Protein C activation peptide inhibits the expression of ICAM-1, VCAM-1, and interleukin-8 induced by TNF-a in human dermal microvascular endothelial cells Protein C activation peptide inhibits the expression of ICAM-1, VCAM-1, and interleukin-8 induced by TNF-a in human dermal microvascular endothelial cells [O] . María Del Socorro Pina-Canseco, Araceli Páez-Arenas, Felipe Massó, 2012

机译：蛋白C激活肽抑制人真皮微血管内皮细胞中TNF-α诱导的ICam-1，VCam-1和白细胞介素-8的表达。蛋白C激活肽抑制ICam-1，VCam-1和白细胞介素的表达由人皮肤微血管内皮细胞中的TNF-α诱导的8

ICAM-1 and VCAM-1 Expression Induced by TNF-a Are Inhibited by A Glutathione Peroxidase Mimic

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