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首页> 外文会议>Beltwide Cotton Conferences >Mechanism of resistance and cross resistance in a laboratory, spinosad-selected strain of the tobacco budworm and resistance in laboratory-selected cotton bollworms
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Mechanism of resistance and cross resistance in a laboratory, spinosad-selected strain of the tobacco budworm and resistance in laboratory-selected cotton bollworms

机译：实验室中抗性和抗抗抗性机理，烟草芽的烟丝芽孢杆菌和实验室棉铃虫抗性的抗性

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A laboratory strain of the tobacco budworm, Heliothis virescens, was selected for high levels of resistance to spinosad, the active ingredient in Tracer~(R). Resistance relative to the parental strain was estimated at 1,068, 314-, and >163-fold by topical, diet, and injected routes of exposure, respectively. Experiments to determine the mechanism of resistance have shown that reduced or delayed penetration of the cuticle, metabolism, or excretion are not significantly different in the resistant strain. Neurophysiological preparations show 1.9- and 1.8-fold reductions of spinosad A-induced inward currents in the resistant strain when spinosad A is applied at in vitro concentrations of 10~(-8) and 10~(-7) M, respectively, suggesting that the selected strain may have decreased neural sensitivity to spinosad A. Reduced inward currents in the resistant strain may or may not be related to the mode of action of the spinosyns. In a further effort to elucidate the mechanism of resistance several pesticides were bioassayed for cross resistance. No cross resistance was found based on comparisons of the LC50s to permethrin, profenofos, indoxacarb, emarnectin benzoate, or acetamiprid, suggesting that the mechanism of resistance in the laboratory selected strain is unique as is the mode of action of the spinosyns. Finally, a laboratory strain of the cotton bollworm, Helicoverpa zea, was selected with spinosad (Tracer~(R)) in artificial diet for 6 generations, resulting in a strain that was 5-fold less susceptible to topically applied technical spinosad.
机译：选择烟草芽虫，Heliothis virescens的实验室菌株，用于高水平的抗刺肌，在特拉克〜（r）中的活性成分。通过局部，饮食和注射曝光途径，估计相对于亲本菌株的抗性估计为1,068,314-，和> 163倍。确定抗性机制的实验表明，在抗性菌株中减少或延迟渗透性，代谢或排泄在抗性菌株中没有显着差异。神经生理制剂在分别在10〜（-8）和10〜（ - 7）m的体外浓度下施用Spinosad A.Pasposad A.princosad A.分别施加致力菌株中的抗性应变中的向内电流的1.9℃和1.8倍。所选择的菌株可以降低对旋光盘A的神经敏感性。抗性菌株中的减少的向内电流可以与尖尖素旋的作用方式有关。在进一步努力阐明抵抗的机制，几种农药是生物测量的抗抗性。无交叉抗药性是基于LC50s的比较，以氯菊酯，丙溴磷，茚虫威，emarnectin苯甲酸盐，或脒发现，这表明电阻的在实验室选择的菌株的机制是独一无二的，因为是多杀菌素的作用方式。最后，用Spinosad（示踪剂〜（R））选择棉铃虫棉花的实验室株6代，导致液体较低易受局部施用的技术旋转肌肉的菌株5倍。

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