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首页> 外文会议>Materials Research Society Symposium >MICROPARTICLES OF ALGINATE CALCIUM GEL MODIFIED BY CHITOSAN FOR PULSATIVE DELIVERY OF RIFAMPICINE
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MICROPARTICLES OF ALGINATE CALCIUM GEL MODIFIED BY CHITOSAN FOR PULSATIVE DELIVERY OF RIFAMPICINE

机译：壳聚糖改性藻酸盐钙凝胶的微粒，用于利福平脉动递送

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The aim of this work is the development of controlled delivery system immobilized by antimicrobial drug rifampicine on the basis of microparticles of alginate calcium gel, modified by natural polymer chitosan. Modified microparticles were obtained by syringed dropwise a solution of rifampicine in solution of sodium alginate was into a mixed solution of chitosan in calcium chloride. The obtained modified alginate microparticles were contained immobilized rifampicine and a surface layer of chitosan. Effects of chithosan concentration and exposure duration on the thickness of polymer coating were determined. For the determination of surface thickness a red congo dye has been used able to form a complex with chitosan. It has been established that with an increase in the concentration of a polymer from 0,3 up to 1,5 mass % the thickness of the modified layer increases from 5 up to 60 mcm, and an increase of the time of gel exposition in a 2,5% solution of chitosan from 30 min to 24 h results in an increase in thickness of a layer from 5 up to 20 mcm respectively. When studying an influence of pH of the medium upon an interaction of alginate and chitosan it was been observed a formation of a polyelectrolyte complex between a chitosan polycation and an alginate polyanion stabilized by ionic bonds. The release of rifampicine from the modified alginate gel particles into a physiological solution with different thickness of a chitosan coating were studied. It was shown that the characteristic maximums on the curve of release observe after 10, 30, 90 and 120 min for the samples without the coating and with the coating thickness of 55, 100 and 150 mcm respectively. The data obtained shown a possibility of the regulation of the rate of rifampicine relase from the modified alginate particles by way of alternation of thickness of the chitosan coating.
机译：这个工作的目的是通过固定化的抗微生物药物利福平藻酸钙凝胶的微粒的基础上控制传送系统的发展，由天然聚合物脱乙酰壳多糖改性。改性的微粒是由注射滴加利福平的藻酸钠的溶液中的溶液到壳聚糖在氯化钙的混合溶液中而获得。所得到的改性的藻酸盐微粒，含有固定化的利福平和脱乙酰壳多糖的表面层。测定chithosan浓度和聚合物涂层的厚度曝光持续时间的影响。对于表面层厚度的测定红色染料刚果已使用能够形成复合物与脱乙酰壳多糖。已经确定，与从0,3到1,5质量％的从5到60亿立方米的改性层的厚度增加在聚合物的浓度的增加，并且在增加的凝胶论述的时间从30分钟至24小时的结果为5到20分别MCM以层的厚度的增加脱乙酰壳多糖2.5％溶液。当在藻酸盐的相互作用研究的介质的pH值的影响和壳聚糖它被观察到地层中的脱乙酰壳多糖和聚阳离子藻酸盐聚阴离子由离子键稳定之间复合物的聚电解质。从改性藻酸盐凝胶颗粒利福平释放到具有不同厚度的壳聚糖涂层的生理溶液进行了研究。结果表明释放的曲线上的特征最大值后10,30，90和120分钟的样品观察不具有涂层，并用分别为55，100和150的MCM涂层厚度。所获得的数据示出利福平RELASE从改性藻酸盐颗粒的速率由壳聚糖涂层的厚度的交替的方式调节的可能性。

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