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首页> 外文会议>Symposium on biomedical materials-drug delivery, implants and tissue engineering >Development of a multiple-lumen nerve cuff utilizing growth stimulant patterns for controlled regeneration
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Development of a multiple-lumen nerve cuff utilizing growth stimulant patterns for controlled regeneration

机译：利用生长兴奋剂测定的控制再生的多腔神经箍的发展

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Silicone rubber multiple-lumen (ML) nerve cuffs were used for side-by-side comparisons of the effectiveness of two varieties of nerve growth stimulants (collagen gel and a gel mixture of collagen, fibronectin, and laminin) for regenerating cables across a 15 mm gap in 10 adult Sprague-Dawley rats. The filling pattern of the six tubes of the multiple-lumen portion of the cuff alternated with the collagen gel and the gel mixture of collagen, fibronectin, and laminin. After an 8 week implantation period, 53percent (32 of 60) of the 0.5 mm diameter lumens displayed successful cable regeneration for both material fillings. The ML cuff experiments demonstrate the ability to bridge a 15 mm gap in the sciatic nerve of the rat by 8 weeks for relatively small diameter conduits in ML cuffs loaded with two varieties of growth stimulants. A more advanced organization including a smaller acellular region fraction and a higher vascularity is seen in the cables from the mixture-filled lumens compared to those in the cables from the collagen-filled lumens.
机译：硅橡胶的多腔（ML）神经箍被用于侧由端的两个品种的神经生长刺激剂（胶原凝胶和胶原蛋白，纤连蛋白的凝胶混合物和层粘连蛋白）的有效性的比较用于跨15再生电缆毫米间隙在10只成年Sprague-Dawley大鼠。与胶原凝胶和胶原蛋白，纤连蛋白和层粘连蛋白的凝胶混合物交替箍的多管腔部分的六个管的填充图案。 8周植入期之后，将0.5mm直径的流明53percent（60 32）显示两种材料馅料成功电缆再生。的ML袖带实验证明由8周，在ML相对小直径管道袖口装载有两个品种生长刺激剂的桥接在大鼠的坐骨神经15mm的间隙的能力。一个更高级的组织，包括更小的无细胞区域馏分和较高的血管被认为是在从相对于那些在来自胶原填充管腔电缆填充混合物管腔的电缆。

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