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首页> 外文会议>NATO advanced research workshop on technological and medical implications of metabolic control analysis >Quantifying the Importance of Regulatory Loops in Homeostatic Control Mechanisms: Hierarchical Control of DNA Supercoiling
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Quantifying the Importance of Regulatory Loops in Homeostatic Control Mechanisms: Hierarchical Control of DNA Supercoiling

机译：量化监管循环在稳态控制机制的重要性：DNA超录的分层控制

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Many regulatory structures in the cell appear to aim at maintaining an optimal cellular state. These are here referred to as homeostatic control mechanisms. After a change in environmental conditions a cell adjusts to return as closely as possible to its previous state. Interestingly, these control mechanisms also function after perturbations of the cellular state itself. Apparently this type of regulatory mechanism is not so much addressed from the extracellular as it is from the intracellular environment, a topic dealt with in this volume in Chapter 26. Although the homeostatic control mechanisms are by definition beneficial to the biological system, they can be a nuisance when trying to engineer it. Attempts to manipulate the system tend to be largely overruled by subsequent adaptation. Part of such homeostatic control mechanisms is embedded in the nature of the kinetics of the catalytic steps in the system. On activation of such a step the product of the reaction iwll increase initially but this increase will lead to both an inhibition of the stimulated step and an activation of the subsequent step in the pathway. IN this way, both enzymes surrounding the intermediate will tend to keep the concentration of the latter constant.
机译：电池中的许多调节结构似乎旨在保持最佳的细胞状态。这些在这里被称为稳态控制机制。在环境条件变化之后，细胞调整以尽可能地返回其先前的状态。有趣的是，这些控制机制还在蜂窝状态本身的扰动后起作用。显然，这种类型的调节机制并不是从细胞外的那样解决，因为它来自细胞内环境，一个主题在第26章中处理了这个体积。虽然稳态控制机制是有益于生物系统的定义，但它们可以是在尝试工程师时造成滋扰。操作系统的尝试往往受到随后的适应性的基本估计。这些稳态控制机制的一部分嵌入了系统中催化步骤的动力学的性质。在这种步骤的激活上，反应IWLL的产物最初增加，但这种增加将导致刺激步骤的抑制和随后的途径中的步骤的活化。以这种方式，两个围绕中间体的酶都会倾向于保持后一种恒定的浓度。

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