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首页> 外文会议>PMSE Symposia >Reactive Multilayered Films Fabricated from Poly(2-alkenyl azlactone)s: Design of Surfaces that Prevent or Promote Cell Adhesion and Bacterial Biofilm Growth
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Reactive Multilayered Films Fabricated from Poly(2-alkenyl azlactone)s: Design of Surfaces that Prevent or Promote Cell Adhesion and Bacterial Biofilm Growth

机译：由聚（2-链烯基Azlactone）S制造的反应性多层薄膜：表面设计，可防止或促进细胞粘附和细菌生物膜生长

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摘要

The ability to prevent or promote the attachment of cells and proteins on surfaces is critical in a wide range of biotechnological applications. Significant advances have been made toward the design of surfaces that promote, prevent, or pattern cell attachment and dictate cell behavior (e.g., self-assembled monolayers (SAMs) of alkanethiols on gold-coated surfaces and appropriately functionalized polymers assembled on surfaces). However, there remains a general need for new materials-based platforms that are (i) chemically robust and stable in physiologically relevant environments, (ii) compatible with the introduction of a broad range of chemical functionality, and (iii) useful for the modification and functionalization of a wide range of materials and surfaces (i.e., substrate-independent). Here, we report a step toward these broad goals through the fabrication of covalently crosslinked and chemically reactive ultrathin films composed of azlactone-functionalized polymers that can be modified readily to promote and/or prevent the attachment of cells on film-coated surfaces.
机译：防止或促进细胞和蛋白质在表面上的附着的能力在各种各样的生物技术应用中至关重要。已经朝着促进，预防或图案附着和规定的细胞行为（例如，在金涂覆的表面上的链烷醇的单层行为（例如，在表面上组装的适当官能化的聚合物）进行显着进展。然而，仍然需要对（i）在生理相关环境中的化学稳健和稳定的基于新材料的平台，（ii）与引入广泛的化学功能，（iii）可用于修改和各种材料和表面的功能化（即，基板无关）。在这里，我们通过制造由共价交联的和化学反应性超薄膜组成的偶氮铁酮官能化聚合物来报告这些宽阔的目标的一步，该聚合物可以容易地改变以促进和/或防止细胞附着在膜涂覆的表面上。

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