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首页> 外文会议>PMSE Symposia >Lamellar to Inverted Hexagonal Phase Transition in DNA Complexes with Calamitic, Discotic, and Cubic Shaped Cationic Lipids
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Lamellar to Inverted Hexagonal Phase Transition in DNA Complexes with Calamitic, Discotic, and Cubic Shaped Cationic Lipids

机译：在DNA复合物中倒六方相转变的层状络合物与古木，椎间盘和立方形状的阳离子脂质

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摘要

Double-stranded DNA condensation with cationic species has represented an important process in not only biological systems but also polymer science field (e.g., coil-globule transition). Especially, DNA-cationic lipid complexes, which are termed as lipoplexes, have received extensive investigations for nonviral gene transfection applications. Thermodynamically, the complexation is driven by the release of small molecule counterions and the electrostatic interaction between negatively charged DNA and positively charged cationic lipids. The efficiency of gene transfection is dictated by many parameters, including cationic and helper lipid classes, surface charge density (or cationic to helper lipid ratio), mesophase morphology of the lipoplexes, cell lines, and so on. In addition, in-vivo gene transfection, different from in-vitro transfection, is complicated by other factors such as targeted delivery. Understanding the structure-function relationship of cationic lipid-based gene transfection therefore becomes an important research topic.
机译：具有阳离子物种的双链DNA凝聚在不仅是生物系统，而且具有聚合物科学领域的重要过程（例如，线圈球过渡）。特别是，被称为脂质的DNA阳离子脂质复合物，对非血管基因转染应用进行了广泛的研究。热力学上，通过释放小分子抗衡离子和带负电荷DNA之间的静电相互作用和带正电荷的阳离子脂质的静电相互作用驱动。基因转染的效率由许多参数决定，包括阳离子和辅助脂肪类，表面电荷密度（或阳离子脂质比），脂质化合物，细胞系等中间相的形态等。此外，不同于体外转染的体内基因转染，靶向递送等其他因素是复杂的。理解阳离子脂质基因转染的结构功能关系成为一个重要的研究主题。

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