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首页> 外文会议>PMSE Symposia >Synthesis of Poly(methyl methacrylate-co- hydroxyethyl methacrylate)-b- Polyisobutylene-b-Poly(methyl methacrylate-co-hydroxyethyl methacrylate)
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Synthesis of Poly(methyl methacrylate-co- hydroxyethyl methacrylate)-b- Polyisobutylene-b-Poly(methyl methacrylate-co-hydroxyethyl methacrylate)

机译：聚（甲基丙烯酸甲酯 - 羟乙基甲基丙烯酸甲酯）-B-聚异丁烯-B-聚（甲基丙烯酸甲酯 - 甲基丙烯酸甲酯）的合成

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摘要

Polyisobutylene (PIB) based block copolymers have attracted considerable attention for biomedical applications. Poly(styrene-b- isobutylene-b-styrene) (SIBS) triblock copolymer is currently employed as the drug carrier matrix for the TAXUSTM Express Paclitaxel-Eluting Coronary Stent system (Boston Scientific Corporation). Since PTx is not miscible with either block in SIBS, the drug forms separate nanosized domains and diffusion of PTx through SIBS is extremely slow. Recently it was reported that the drug release rate can be modulated by modifying the polarity of the end blocks. For instance, replacing S with acetoxystyrene yielded an increased PTx release rate, while substitution with hydroxystyrene resulted in an initial burst release followed by a slower sustained release.
机译：基于聚异丁烯（PIB）的嵌段共聚物引起了对生物医学应用的相当大的关注。 Poly（苯乙烯-B-异丁烯-B-苯乙烯）（SIBS）三嵌段共聚物目前用于TACKUSM Express紫杉醇洗脱冠状动脉渣系统的药物载体基质（波士顿科学公司）。由于PTX在SIB中的任何一个嵌段中不混溶，因此药物形成单独的纳米域，并且PTX通过SIB的扩散非常慢。最近据报道，通过修改端块的极性，可以调制药物释放速率。例如，用乙酰氧基苯乙烯替代S增加的PTX释放速率，同时用羟基苯乙烯取代导致初始爆发释放，然后较慢持续释放。

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