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首页> 外文会议>PMSE Symposia >Electrospun Mats of Genistein-Modified Blends of Poly(D,L-Lactic Acid) and Poly(ethylene oxide) with Improved Anti- oxidant and Anti-inflammatory Properties
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Electrospun Mats of Genistein-Modified Blends of Poly(D,L-Lactic Acid) and Poly(ethylene oxide) with Improved Anti- oxidant and Anti-inflammatory Properties

机译：具有改善的抗氧化剂和抗炎性能的聚（D，L-乳酸）和聚（环氧乙烷）的Genistein改性混合物的电纺垫和抗炎性能

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摘要

Phytoestrogens are hormones derived from plants such as whole grains, beans, and fruit, exhibiting many health benefits. Among phytoestrogens, genistein (5,7,4'-trihydroxyisoflavone) is especially attractive because it is a potent tyrosine kinase inhibitor and it possesses anti-oxidant activity. Additionally, it can inhibit skin damage caused by UV irradiation[1] and stimulate human fibroblast collagen synthesis. [2] Genistein has been categorized into biopharmaceutical classification system class II of compound based on its low solubility (only 3×10-6 mol·L-1 in water) and high permeability. [3] Poor solubility has been a major impediment to the preclinical evaluation. Poly(D,L- lactic acid) (PDLLA) is a biocompatible and biodegradable polymer, derived from bacterial fermentation of renewable resources. PDLLA electrospun fibers have been used widely as biomaterials in tissue engineering. [4] With the huge surface area to volume ratio and microporous structure, electrospun mats could readily start signaling pathway and attract fibroblasts to the derma layer, which can excrete extracellular matrix components to repair damage tissue. [5] However, PLA suffers some limitations, especially brittleness and hydrophobicity. In order to remedy these deficiencies of PDLLA, poly(ethylene oxide) (PEO) which is a flexible, water-soluble and biocompatibility polymer, is selected as the counterpart for its blend with PDLLA. Moreover, PEO may improve the solubility of genistein. [6-7] Therefore, genistein- incorporated PDLLA/PEO electrospun mats is an interesting route to obtain biomedical materials for wound dressing with enhanced anti- oxidant and anti-inflammatory properties.
机译：植物雌激素是衍生自植物，如全谷物，豆类和水果等植物，表现出许多健康益处。在植物雌激素中，Genistein（5,7,4'-Trihydroxyisoflavone）特别有吸引力，因为它是效力酪氨酸激酶抑制剂，并且它具有抗氧化剂活性。另外，它可以抑制紫外线照射引起的皮肤损伤[1]并刺激人成纤维细胞胶原合成。 [2]基于其低溶解度（仅3×10-6mol-1在水中）和高渗透率，Genistein已被分类为化合物的生物制药分类系统II类II类。 [3]溶解度不良是临床前评价的主要障碍。聚（D，L-乳酸）（PDLLA）是一种生物相容性和可生物降解的聚合物，来自可再生资源的细菌发酵。 PDLLA电纺纤维已被广泛用于组织工程中的生物材料。通过巨大的表面积与体积比和微孔结构，电纺垫可以容易地开始信号通路并吸引成纤维细胞到Derma层，可以排出细胞外基质组分以修复损伤组织。 [5]然而，PLA遭受一些局限性，尤其是脆性和疏水性。为了弥补这些PDLLA的缺乏，选择是柔性的水溶性和生物相容性聚合物的聚（环氧乙烷）（PEO）作为其与PDLLA共混物的对应物。此外，PEO可以改善甘氨酸的溶解度。因此，Genistein掺入的PDLLA / PEO Electrom雾垫是获得伤口敷料的生物医学材料的有趣途径，具有增强的抗氧化剂和抗炎特性。

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