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首页> 外文会议>PMSE Symposia >Inhibition of Pancreatic Cancer Cell Lines by Dibutyltin Polyamines Derived from 4,6- Diaminopyrimidines
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Inhibition of Pancreatic Cancer Cell Lines by Dibutyltin Polyamines Derived from 4,6- Diaminopyrimidines

机译：二丁基锡多胺抑制胰腺癌细胞系衍生自4,6-二氨基嘧啶的多胺

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Pancreatic cancer afflicts close to 32,000 individuals each year in the United States and 168,000 worldwide, and nearly all patients die from the ravages of their disease within 3 to 6 months after detection. It is the fourth leading cause of cancer death worldwide behind lung (1.3 million deaths/year), stomach (1 million deaths/year), and liver (660,000 deaths/year). Treatment of pancreatic cancer is rarely successful as this disease typically metastasizes prior to detection. Current therapies consist of surgery and, possibly, radiation and chemotherapy. Standard chemotherapy for patients with locally contained cancer includes gemcitabine. Gemcitabine has been demonstrated to improve the quality of life through better pain control, adequate performance status, decreased analgesic consumption, shrinkage of tumor, and prolonged survival. Radiation therapy is usually ineffective except as an adjunct to chemotherapy or as a palliative measure. There is no chemotherapy for metastasized pancreatic cancer. More organotin compounds are available commercially than any other metal-containing organometallics. Further, more organotin compounds have undergone testing as potential anticancer agents than any other single group of compounds. We have synthesized a number of organotin-containing polymers with many of them exhibiting good wide-spread inhibition of a number of cancer cell lines including those associated with lung, bone, colon, breast, ovarian, and prostrate cancer.
机译：胰腺癌在美国每年折磨12,000人，全球168,000名，几乎所有患者都会在检测后3至6个月内从疾病的蹂躏中死亡。它是全世界肺部（130万人死亡/年），胃病（死亡/年）和肝脏（660,000人死亡/年）的第四个主要原因。胰腺癌的治疗很少成功，因为这种疾病通常在检测之前转移。目前的疗法包括手术，可能是辐射和化疗。含有局部癌症患者的标准化疗包括吉西他滨。吉西他滨已经证明通过更好的疼痛控制，充分的性能状态，减少镇痛消费，肿瘤收缩和延长的存活率来提高生活质量。除了化学疗法或姑息量之外，放射治疗通常是无效的。没有化​​疗促使胰腺癌。更多有机锡化合物可商购比任何其他含金属的有机金属。此外，更有机锡化合物经历测试作为潜在抗癌剂比化合物中的任何其他一个组。我们已合成了一些含有机锡的聚合物的其中许多表现出良好的广泛分布抑制许多肿瘤细胞系包括与肺癌，骨癌，结肠癌，乳腺癌，卵巢癌和前列腺癌有关的那些组成。

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