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首页> 外文会议>Conference on advanced environmental and chemical sensing technology >Control of Protein Adsorption for MEMs and Microfluidic Applications on Silicon Surfaces using Silane Based Self-Assembled Monolayers of an Oligo(ethylene oxide) Derivative.
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Control of Protein Adsorption for MEMs and Microfluidic Applications on Silicon Surfaces using Silane Based Self-Assembled Monolayers of an Oligo(ethylene oxide) Derivative.

机译：使用硅烷（环氧乙烷）衍生物的硅烷自组装单层对硅表面上的MEMS和微流体应用的控制对蛋白质吸附。

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摘要

Microfabricated devices are becoming increaisngly improtant in biotechnology, expecially in the areas of drug delviery, biological fluid analysis, and biological sensors. Interactions betwene fluid constituents and device surfaces become improtant when device dimensions reach the micrometer scale. We are reporting hte ysnthesis and application of an octyl trichlorosilane ehter of a short chain mono mehtylated poly(ethylene glycol) (PEG8,7) for control of protein adsorption on silicon surface.s Self-assembled monolayers (SAMs) of the PEG8.7, a commercially available long chain poly(ethylene glycol) silane (PEG 5000), and 1H,1H,2H,2H,-perfluorooctyltrichlorosilane (13F) were prepared. These three SAM surfaces and uncoated silicon oxide were compared for control of protein adsorption of bovine serum albumin (BSA) under nonflow conditions. PEG8,7 was shown to be the best surface for inhibiting protein adsorption. The surfaces were analyzed using X-ray photoelectron spectroscopy (XPS) to quantify protein adsorption.
机译：微制造设备在生物技术方面变得严重态度，在药物谵妄，生物流体分析和生物传感器的区域方面变得严重。当器件尺寸到达微米尺度时，流体成分和器件表面之间的相互作用变得更为啰嗦。我们报道了HTE Ysnthesis和辛基三氯硅烷eHTER的短链Mono Mehtlylated Poly（乙二醇）（PEG8,7），用于控制硅表面上的蛋白质吸附。PEG8.7的自组装单层（Sams） ，制备市售的长链聚（乙二醇）硅烷（PEG 5000）和1H，1H，2H，2H，-PEROROOROCTHLOLOSILANE（13F）。将这三个SAM表面和未涂覆的氧化硅进行比较，以控制在非流条件下牛血清白蛋白（BSA）的蛋白质吸附。 PEG8,7被证明是用于抑制蛋白质吸附的最佳表面。使用X射线光电子能谱（XPS）分析表面以定量蛋白质吸附。

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