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首页> 外文会议>International Symposium on Ganoderma Research >Protection Against Alloxan-induced Diabetes by Ganoderma lucidum Polysaccharides in Mice
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Protection Against Alloxan-induced Diabetes by Ganoderma lucidum Polysaccharides in Mice

机译：对小鼠Ganoderma Lucidum多糖的糖氧诱导的糖尿病保护

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摘要

This study was undertaken to investigate the protective effect against alloxan-induced diabetes in mice by Ganoderma lucidum polysaccharides (GL-PS) isolated from the fruiting body of Ganoderma lucidum (Leyss. Ex Fr.) Karst. GL-PS dose-dependently increased serum insulin contents and reduced serum glucose levels when given intragastically for continuous 10 days in alloxan-induced diabetic mice. It was found that the liver and pancreas homogenates had higher lipid peroxidation products in alloxan administered mice than in the GL-PS-treated animals. GL-PS also increase the activities of liver and pancreas catalase and pancreas GSH-px significantly in alloxan-induced diabetic mice. In addition, aldehyde fuchsin staining revealed that alloxan caused nearly all the β cells to disappear from in the pancreatic islets, while GL-PS could partly protect the β cells from necrosis. The effect of GL-PS was maximum at 200mg/kg. These results indicate that GL-PS is able to lessen the biochemical damage induced by alloxan in mice and this might be due, in part, to its antioxidant action.
机译：本研究旨在探讨Ganoderma Lucidum多糖（GL-PS）与灵芝（Leyss.ex Fr.）喀斯特的果实分离的Ganoderma lucidum多糖（GL-PS）对小鼠对小鼠糖尿病的保护作用。 GL-PS剂量依赖性增加血清胰岛素含量，并在甲氧烷诱导的糖尿病小鼠中连续10天内造成10天的血清胰岛素含量和减少血清葡萄糖水平。结果发现，肝脏和胰腺均匀素在阿萨克兰施用小鼠中具有更高的脂质过氧化产物，而不是GL-PS处理的动物。 GL-PS还在阿洛昔班诱导的糖尿病小鼠中显着增加肝脏和胰腺过氧化氢酶和胰腺GSH-PX的活性。此外，醛葡萄蛋白染色揭示了阿仑昔他群造成的几乎所有β细胞在胰岛中都消失，而GL-PS可以部分保护β细胞免受坏死的影响。 GL-PS的效果最大为200mg / kg。这些结果表明，GL-PS能够减少小鼠中阿昔烷诱导的生物化学损伤，这部分可能是其抗氧化作用。

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