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A model of inositol 1,4,5-trisphosphate and calcium dynamics in single cells following metabotropic receptor activation

机译：代谢受体激活后单细胞肌醇1,4,5-三磷酸盐和钙动力学模型

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The application of external agonist to purinergic metabotropic receptors on single cells leads to transient inositol 1,4,5-trisphosphate (IP_3) and calcium (Ca~(2+)) responses. A mathematical model is formulated for the processes governing these responses, including the regulation of the receptor activity, the G-protein cascade and the cytosolic Ca~(2+) and IP_3 dynamics. This model is used to reproduce experimental observations on the extent of desensitization and sequestration of the P_2Y_2 receptor following its activation by uridine triphosphate and also the IP_3 and Ca~(2+) responses following this activation.

机译：外部激动剂在单细胞上施用到嘌呤能性代谢受体导致瞬时肌醇1,4,5-三磷酸（IP_3）和钙（Ca〜（2+））反应。配制了数学模型，用于治疗这些反应的过程，包括受体活性的调节，G蛋白级联和细胞溶质Ca〜（2+）和IP_3动力学。该模型用于再现实验观察结果，在其尿苷三磷酸盐激活后，在该激活后的IP_3和Ca〜（2+）反应后，对P_2Y_2受体的脱敏和封存的程度。

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《Computational neuroscience meeting》|2003年||共6页
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Greg Lemon; William G. Gibson; Max R. Bennett;
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中图分类系统科学;
关键词
calcium; inositol 1,4; 5-trisphosphate; metabotropic receptor; endoplasmic reticulum; G-protein cascade;

机译：钙;肌醇1,4;5-三磷酸盐;代谢性受体;内质网;G蛋白级联;

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1. A model of inositol 1,4,5-trisphosphate and calcium dynamics in single cells following metabotropic receptor activation [J] . Greg Lemon, William G. Gibson, Max R. Bennett Neurocomputing . 2003,第Jun期

机译：代谢型受体激活后单细胞中肌醇1,4,5-三磷酸和钙动力学的模型
2. Metabotropic receptor activation, desensitization and sequestration-I: modelling calcium and inositol 1,4,5-trisphosphate dynamics following receptor activation [J] . Lemon G., Gibson WG., Bennett MR. Journal of Theoretical Biology . 2003,第1期

机译：代谢型受体激活，脱敏和螯合-I：受体激活后模拟钙和肌醇1,4,5-三磷酸酯动力学
3. Activating calcium release through inositol 1,4,5-trisphosphate receptors without inositol 1,4,5-trisphosphate [J] . Martin D. Bootman, Michael J. Berridge, H. Llewelyn Roderick Proceedings of the National Academy of Sciences of the United States of America . 2002,第11期

机译：通过肌醇1,4,5-三磷酸酯受体激活钙释放，而没有肌醇1,4,5-三磷酸酯
4. A model of inositol 1,4,5-trisphosphate and calcium dynamics in single cells following metabotropic receptor activation [C] . Greg Lemon, William G. Gibson, Max R. Bennett Computational neuroscience meeting . 2003

机译：代谢受体激活后单细胞肌醇1,4,5-三磷酸盐和钙动力学模型
5. Identification of intracellular calcium receptors (Inositol 1,4,5 -trisphosphate and ryanodine) during maturation in bovine oocytes. [D] . Wang, Lin. 2000

机译：鉴定牛卵母细胞成熟过程中的细胞内钙受体（肌醇1,4,5-三磷酸和ryanodine）。
6. Activating calcium release through inositol 145-trisphosphate receptors without inositol 145-trisphosphate [O] . Martin D. Bootman, Michael J. Berridge, H. Llewelyn Roderick 2002

机译：通过肌醇145-三磷酸酯受体激活钙释放而没有肌醇145-三磷酸酯
7. Activating calcium release through inositol 1,4,5-trisphosphate receptors without inositol 1,4,5-trisphosphate [O] . Bootman MD, Berridge MJ, Roderick H Llewelyn 2002

机译：通过肌醇1,4,5-三磷酸酯受体激活钙释放，而没有肌醇1,4,5-三磷酸酯

A model of inositol 1,4,5-trisphosphate and calcium dynamics in single cells following metabotropic receptor activation

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