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Inositol trisphosphate and calcium oscillations

机译：肌醇三磷酸和钙振荡

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InsP_3 has two important functions in generating Ca~(2+) oscillations. It releases Ca~(2+) from the internal store and it can contribute to Ca~(2+) entry. A hypothesis has been developed to describe a mechanism for Ca2+ oscillations with particular emphasis on the way agonist concentration regulates oscillator frequency. The main idea is that the InsP_3 receptors are sensitized to release Ca~(2+) periodically by cyclical fluctuations of Ca~(2+) within the lumen of the endoplasmic reticulum. Each time a pulse of Ca~(2+) is released, the luminal level of Ca~(2+) declines and has to be replenished before the InsP3 receptors are resensitized to deliver the next pulse of Ca~(2+). It is this loading of the internal store that explains why frequency is sensitive to external Ca~(2+) and may also account for how variations in agonist concentration are translated into changes in oscillation frequency. Variations in agonist-induced entry of external Ca~(2+), which can occur through different mechanisms, determine the variable rates of store loading responsible for adjusting the sensitivity of the InsP_3 receptors to produce the periodic pulses of Ca~(2+). The Ca~(2+) oscillator is an effective analogue-to-digital converter in that variations in the concentration of the external stimulus are translated into a change in oscillator frequency.
机译：Insp_3在生成CA〜（2+）振荡时具有两个重要功能。它从内部商店释放CA〜（2+），它可以贡献CA〜（2+）条目。已经开发了一个假设，以描述Ca2 +振荡的机制，特别强调激动剂浓度调节振荡器频率。主要思想是，通过内质网内腔内的Ca〜（2+）的周期性波动，敏感性敏感性地敏感以释放Ca〜（2+）。每次释放Ca〜（2+）的脉冲时，Ca〜（2+）的腔水平下降，必须在恢复Insp3受体以提供下一个Ca〜（2+）的脉冲之前补充。这是对内部商店的加载，解释了频率对外部CA〜（2+）敏感的原因，并且还可能考虑激动剂浓度的变化转换为振荡频率的变化。激动剂诱导的外部Ca〜（2+）进入的变化，其可以通过不同的机制发生，确定负责调节Insp_3受体的灵​​敏度的商店装载的可变速率，以产生Ca〜（2+）的周期性脉冲。 CA〜（2+）振荡器是一种有效的模拟 - 数字转换器，即外部刺激浓度的变化被翻译成振荡器频率的变化。

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