Analyte-Receptor Binding Kinetics on Microarrays

机译：微阵列对分析物受体结合动力学

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A fractal analysis is presented for modeling the binding kinetics of analytes in solution to receptors immobilized on a microarray surface. A dual-fractal analysis is used to model the data for cell binding assays on microarrays. A kinetic analysis of the data taken from the literature provides a better understanding of the interactions occurring on the microarray surfaces. The binding rate coefficient is linked to the degree of heterogeneity present on the microarray surface where ever possible. The analysis should provide further physical insights into the binding reactions occurring on microarray surfaces.

机译：提出了一种分形分析，用于将分析物的结合动力学建模，其在溶液中固定在微阵列表面上的受体中。双分形分析用于对微阵列进行细胞结合测定的数据。从文献中获取的数据的动力学分析提供了更好地理解在微阵列表面上发生的相互作用。结合速率系数与在可能的微阵列表面上存在的异质性程度相关联。分析应提供进一步的物理见解，进入在微阵列表面上发生的结合反应。

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来源
《AIChE Annual Meeting》|2003年||共6页
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作者
Harshala D. Butala; Anand Ramakrishnan; Ajit Sadana;
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中图分类 TM911-53;
关键词
Microarray; dual-fractal analysis; degree of heterogeneity; binding rate coefficients;

机译：微阵列;双分形分析;异质程度;结合速率系数;

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专利

1. Analyte-receptor binding kinetics for biosensor applications an analysis of the influence of the fractal dimension on the binding rate coefficient [J] . Sadana A. Applied biochemistry and biotechnology, Part A. enzyme engineering and biotechnology . 1998,第2a3期

机译：生物传感器应用中分析物与受体的结合动力学分析分形维数对结合速率系数的影响
2. Analyte-receptor binding kinetics for biosensor applications: A single-fractal and a dual-fractal analysis of the influence of the fractal dimension on the binding rate coefficient [J] . Ramakrishnan A., Sadana A. Journal of Colloid and Interface Science . 1998,第2期

机译：生物传感器应用中分析物-受体的结合动力学：分形维数对结合速率系数的影响的单分形和双分形分析
3. An analysis of analyte-receptor binding kinetics for biosensor applications: Influence of the fractal dimension on the binding rate coefficient [J] . Sadana A. Journal of Colloid and Interface Science . 1998,第1期

机译：生物传感器应用中分析物-受体结合动力学的分析：分形维数对结合速率系数的影响
4. Analyte-Receptor Binding Kinetics on Microarrays [C] . Harshala D. Butala, Anand Ramakrishnan, Ajit Sadana AIChE annual meeting . 2003

机译：微阵列上的分析物-受体结合动力学
5. A fractal analysis of analyte-receptor binding and dissociation kinetics for biosensor and biomedical applications. [D] . Ramakrishnan, Anand. 2002

机译：用于生物传感器和生物医学应用的分析物-受体结合和解离动力学的分形分析。
6. Use of hybridization kinetics for differentiating specific from non-specific binding to oligonucleotide microarrays [O] . Hongyue Dai, Michael Meyer, Sergey Stepaniants, 2002

机译：杂交动力学用于区分对寡核苷酸微阵列的特异性与非特异性结合的方法
7. Kinetic Analysis for Analyte-Receptor Binding and Dissociation in Biosensor Applications: a Fractal Analysis [O] . Ajit Sadana 2001

机译：体传感器应用中分析物受体结合和解离的动力学分析：分形分析

Analyte-Receptor Binding Kinetics on Microarrays

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