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FLUID BED COATING PROCESS FOR MODIFIED RELEASE APPLICATIONS

机译：改性释放应用的流化床涂布方法

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摘要

Wurster process (bottom spray fluid bed coating process) is a process of choice for coating of multiparticulates to produce modified or controlled release dosage forms. The unique features of the Wurster process include air distribution plates (up bed and down bed plates) and partition that organize fluidization of particles through the "coating zone". The nozzle is mounted at the bottom of a product container. The short distance between coating materials and particles during.the coating process and the concurrent spray (same direction of particle flow and spray droplets) minimize spray drying. This principle contributes to high coating uniformity and coating efficiency of the Wurster process. This process can be used to produce pellets by drug layering process, follow by polymer coating to obtain modified or controlled drug release. The fluidization pattern of particles is controlled by air distribution plates, partition height, and process air volume. Coating process parameters that mainly control the process include inlet air temperature, atomization air pressure/volume, and spray rate. Formulation aspect such as composition and solid content of the coating preparation can affect the drug release from the pellets.
机译：Wurster Process（底部喷雾流体床涂层工艺）是涂覆多颗粒以产生改性或控释剂型的选择方法。 Wurster Process的独特特征包括空气分配板（上床床板）和通过“涂层区”组织颗粒的流化的隔板。喷嘴安装在产品容器的底部。涂层材料和颗粒之间的短距离在涂覆过程和涂布过程和同时喷雾（颗粒流动和喷雾液滴相同）中最小化喷雾干燥。该原理有助于纯粹过程的高涂层均匀性和涂布效率。该方法可用于通过药物分层工艺生产颗粒，通过聚合物涂层遵循以获得改性或受控药物释放。颗粒的流化图案由空气分配板，隔板和工艺空气量控制。涂层工艺参数主要控制过程包括入口空气温度，雾化气压/体积和喷雾速率。配方方面，例如涂料制剂的组成和固体含量可以影响来自颗粒的药物释放。

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