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首页> 外文会议>International Conference on Synchrotron Radiation Instrumentation >XANES Spectral Changes of Hydrated Deoxyribose Induced by K-Shell Ionization of Oxygen
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XANES Spectral Changes of Hydrated Deoxyribose Induced by K-Shell Ionization of Oxygen

机译：氧壳电离氧诱导水合脱氧氧的XANES光谱变化

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We investigated the initial process of DNA strand breakage induced by ionizing radiation by recording XANES spectra of hydrated deoxyribose (dR) films before and after K-shell ionization of oxygen. The experiments were performed on beamline BL23SU at SPring-8, Japan. The hydrated dR films were prepared by exposing the cooled dR film surface to water vapor. The XANES spectra were then obtained by measuring the sample drain current. The soft X-ray irradiation treatment led to an increase in the intensity of the π*(C=O) peak (around 532 eV) and a decrease in the intensity of the σ*(C-O) peak (around 538 eV). Furthermore, a characteristic peak was observed at around 534-536 eV. in the hydrated dR film after irradiation. This peak, which was ascribed to a newly formed carboxyl group, was not observed in the XANES spectrum of the dry dR film after irradiation. This carboxyl group was considered to originate from the reaction of a nearby water molecule with the carbonyl group produced by the direct ionization of dR. This structure may be formed at the strand-break termini of DNA after radiation damage. Therefore, waters of hydration may play a protective role against irreparable strand breakage.
机译：我们研究了通过在氧气前后的k-壳电离之前和之后记录水合的脱氧（DR）膜的Xanes光谱来诱导通过电离辐射诱导的DNA链断裂的初始过程。在日本春天8，在梁线BL23SU上进行了实验。通过将冷却的DR膜表面暴露于水蒸气来制备水合的DR膜。然后通过测量样品漏极电流来获得XANES光谱。软X射线照射处理导致π*（c = o）峰（约532eV）的强度的增加，并降低σ*（c-o）峰值的强度（约538ev）。此外，在大约534-536eV中观察到特征峰。在照射后在水合的DR膜中。在照射后，在干燥DR膜的XANES光谱中未观察到新形成的羧基的该峰。认为该羧基源自附近的水分子与通过DR直接电离产生的羰基的反应。在辐射损伤后，可以在DNA的股线断裂末端形成该结构。因此，水合水域可能对无法弥补的链破裂起到保护作用。

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