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首页> 外文会议>Conference on monitoring food safety, agriculture, and plant health >Antimicrobial Peptides: A Review of How Peptide Structure Impacts Antimicrobial Activity
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Antimicrobial Peptides: A Review of How Peptide Structure Impacts Antimicrobial Activity

机译：抗微生物肽：综述肽结构如何影响抗微生物活性

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Antimicrobial peptides (AMPs) have been discovered in insects, mammals, reptiles, and plants to protect against microbial infection. Many of these peptides have been isolated and studied exhaustively to decipher the molecular mechanisms that impart protection against infectious bacteria, fungi, and viruses. Unfortunately, the molecular mechanisms are still being debated within the scientific community but valuable clues have been obtained through structure/function relationship studies. Biophysical studies have revealed that cecropins, isolated from insects and pigs, exhibit random structure in solution but undergo a conformational change to an amphipathic **-helix upon interaction with a membrane surface. The lack of secondary structure in solution results in an extremely durable peptide able to survive exposure to high temperatures, organic solvents and incorporation into fibers and films without compromising antibacterial activity. Studies to better understand the antimicrobial action of cecropins and other AMPs have provided insight into the importance of peptide sequence and structure in antimicrobial activities. Therefore, enhancing our knowledge of how peptide structure imparts function may result in customized peptide sequences tailored for specific applications such as targeted cell delivery systems, novel antibiotics and food preservation additives. This review will summarize the current state of knowledge with respect to cell binding and antimicrobial activity of AMPs focusing primarily upon cecropins.
机译：在昆虫，哺乳动物，爬行动物和植物中发现了抗微生物肽（AMPs）以防止微生物感染。这些肽中的许多已经被彻底分离和研究，以破译赋予传染性细菌，真菌和病毒保护的分子机制。不幸的是，通过结构/功能关系研究，分子机制仍在科学界仍在争论，但是已经通过结构/功能关系研究获得了有价值的线索。生物物理学研究表明，从昆虫和猪中分离的Cecropins，在溶液中表现出随机结构，但在与膜表面相互作用时经历构象变化，对两亲的** - 螺旋。溶液中缺乏次要结构导致极其耐用的肽，能够在不影响抗菌活性的情况下存活地暴露在高温，有机溶剂和薄膜和薄膜中的暴露。为了更好地了解CeCropins和其他安培的抗微生物作用已经为肽序列和结构在抗微生物活性中的重要性提供了深入。因此，提高我们对肽结构如何赋予功能的知识可能导致针对特定应用，例如靶向细胞输送系统，新型抗生素和食品保存添加剂的定制肽序列。本综述将总结当前知识状态，相对于主要的AMPS的细胞结合和抗微生物活性主要关注CECROPINS。

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