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首页> 外文会议>Shanghai International Conference on Laser Medicine and Surgery >Photodynamic therapy for Implanted VX2 Tumor in Rabbit Brains
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Photodynamic therapy for Implanted VX2 Tumor in Rabbit Brains

机译：兔脑中植入的Vx2肿瘤的光动力学疗法

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摘要

To evaluate the therapeutic effect and the safety of single photodynamic therapy (PDT) with hematoporphyrin derivative produced in China, 60 New Zealand adult rabbits with VX2 tumor implanted into the brain were divided randomly into non-PDT-group and PDT-group. 36 rabbits of the PDT-group were performed photodynamic therapy. The survival time, neurological deteriorations, intracranial pressure (ICP), histology, pathology, tumor volume and brain water content were measured. Other 12 rabbits were received hematoporphyrin derivative and light irradiation of the normal brain. The ICP, histology, pathology, and brain water content were measured. The result indicated that Simple PDT may elongate the average survival time of the rabbits with VX2 tumors significantly; kill tumor cells; cause transient brain edema and increase ICP, but it is safe to be used in treating brain tumor.
机译：为了评估在中国生产的血液卟啉衍生物的单一光动力治疗（PDT）的治疗效果和安全性，将60个新西兰成年兔植入大脑中的Vx2肿瘤随机分成非PDT-GROM和PDT-GROUP。 PDT-组的36只兔子进行光动力疗法。测量生存时间，神经劣化，颅内压（ICP），组织学，病理学，肿瘤体积和脑水含量。接受了其他12只兔子血卟啉衍生物和普通脑的光照射。测量ICP，组织学，病理学和脑含水量。结果表明，简单的PDT可以显着伸长兔的平均存活时间;杀死肿瘤细胞;导致瞬态脑水肿并增加ICP，但可防止用于治疗脑肿瘤。

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