DISCOVERING MOTIFS WITH TRANSCRIPTION FACTOR DOMAIN KNOWLEDGE

机译：用转录因子域知识发现图案

获取原文

页面导航

摘要
著录项
相似文献
相关主题

摘要

We introduce a new motif-discovery algorithm, DIMDom, which exploits two additional kinds of information not commonly exploited: (a) the characteristic pattern of binding site classes, where class is determined based on biological information about transcription factor domains and (b) posterior probabilities of these classes. We compared the performance of DIMDom with MEME on all the transcription factors of Drosophila with at least one known binding site in the TRANS FAC database and found that DOMDom outperformed MEME with 2.5 times the number of successes and 1.5 times in the accuracy in finding binding sties and motifs.

机译：我们介绍了一种新的主题发现算法，它利用了两种不公布的其他信息：（a）绑定站点类的特征模式，基于关于转录因子域和（b）后的生物学信息来确定类别的类别这些课程的概率。将DIFM与MEME的性能进行了比较了Drosophila的所有转录因子与反式FAS数据库中的至少一个已知的结合位点进行了比较，发现Domdom在寻找装订阶层的成功次数和1.5倍的情况下表现优于2.5倍的模拟。和主题。

著录项

来源
《Pacific Symposium on Biocomputing》|2007年||共12页
会议地点
作者
HENRY C.M. LEUNG; FRANCIS Y.L. CHIN; BETHANY MY. CHAN;
展开▼
作者单位

展开▼
会议组织
原文格式 PDF
正文语种
中图分类计算机的应用;
关键词

相似文献

外文文献
中文文献
专利

1. A proximal promoter domain containing a homeodomain-binding core motif interacts with multiple transcription factors, including HoxA5 and Phox2 proteins, and critically regulates cell type-specific transcription of the human norepinephrine transporte [J] . Kim CH, Hwang DY, Park JJ, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2002,第7期

机译：包含同源域结合核心基序的近端启动子结构域与多种转录因子（包括HoxA5和Phox2蛋白）相互作用，并严格调节人去甲肾上腺素转运蛋白的细胞类型特异性转录
2. Structural Determination of Functional Domains in Early B-cell Factor (EBF) Family of Transcription Factors Reveals Similarities to Rel DNA-binding Proteins and a Novel Dimerization Motif [J] . Marina I. Siponen, Magdalena Wisniewska, Lari Lehti?, The Journal of biological chemistry . 2010,第34期

机译：早期B细胞因子（EBF）转录因子的功能域的结构测定揭示了与Rel DNA结合蛋白和新型二聚体基序的相似性
3. The Transcription Factor Sterile Alpha Motif (SAM) Pointed Domain-containing ETS Transcription Factor (SPDEF) Is Required for E-cadherin Expression in Prostate Cancer Cells [J] . Mintu Pal, Sweaty Koul, Hari Koul The Journal of biological chemistry . 2013,第17期

机译：在前列腺癌细胞中的E-Cadherin表达需要转录因子无菌α基序（SAM）尖端的域的ETS转录因子（SPDEF）
4. DISCOVERING MOTIFS WITH TRANSCRIPTION FACTORDOMAIN KNOWLEDGE [C] . RECOMB Satellite Workshop on Regulatory Genomics . 2008

机译：用转录因子知识发现主题
5. The GRIK-SnRK1 Kinase Cascade: Characterizing Phosphorylation of TCP Transcription Factors and Motifs in Arabidopsis Proteins. [D] . Greeley, Laura Ann. 2016

机译：GRIK-SnRK1激酶级联反应：表征拟南芥蛋白中TCP转录因子和基序的磷酸化。
6. A Proximal Promoter Domain Containing a Homeodomain-Binding Core Motif Interacts with Multiple Transcription Factors Including HoxA5 and Phox2 Proteins and Critically Regulates Cell Type-Specific Transcription of the Human Norepinephrine Transporter Gene [O] . Chun-Hyung Kim, Dong-Youn Hwang, Jae-Joon Park, 2002

机译：一个最近的启动子域包含一个同源域结合核心母题与多个转录因子包括HoxA5和Phox2蛋白相互作用并严重调节人类去甲肾上腺素转运蛋白基因的细胞类型特异性转录。
7. A Proximal Promoter Domain Containing a Homeodomain-Binding Core Motif Interacts with Multiple Transcription Factors, Including HoxA5 and Phox2 Proteins, and Critically Regulates Cell Type-Specific Transcription of the Human Norepinephrine Transporter Gene [O] . Chun-Hyung Kim, Dong-Youn Hwang, Jae-Joon Park, 2002

机译：含有同种型γ结合核心基序的近端启动子结构域与多种转录因子相互作用，包括Hoxa5和Phox2蛋白，并重要调节人脑肾上腺素转运蛋白的细胞类型的转录

DISCOVERING MOTIFS WITH TRANSCRIPTION FACTOR DOMAIN KNOWLEDGE

摘要

著录项

相似文献

相关主题

期刊订阅