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Innovative Application of Optical Techniques to Comprehensive Study the Etiology of Osteoarthritis

机译：光学技术的创新应用综合研究骨关节炎的病因

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Osteoarthritis is a painful condition, causing restricted mobility in the articular joints. In this paper we present a review of different optical techniques that might be used to clarify the etiology of degeneration of connective joint tissues, such as bone and articular cartilage. Significant correlation (R~2 = 0.8) between bone mineral density and scattering coefficient of cortical bone tissue are found by using Integrating Sphere Technique. Optical Coherence Tomography and Polarization-Sensitive Optical Coherence Tomography images of cartilage tissue are presented. They were performed as series of angle-dependant measurements for different location along the surface. Method for spatial mapping the birefringence of equine articular cartilage is proposed. Variations in band spacing of birefringence obtained from visually healthy and abnormal cartilage samples are compared. Visible osteoarthritic lesions are characterized by a loss of the regular birefringence bands shown by normal cartilage. We discuss the hypothesis that some of these variations may be due to changes in intrinsic structure of tissue.
机译：骨关节炎是一种痛苦的条件，导致关节关节中的受限制的流动性。在本文中，我们介绍了不同光学技术的综述，该技术可用于阐明结缔组织组织的退化的病因，例如骨和关节软骨。通过使用集成球技术发现骨矿物密度和皮质骨组织散射系数之间的显着相关性（R〜2 = 0.8）。呈现了软骨组织的光学相干断层扫描和偏振敏感光学相干断层扫描图像。它们是由沿着表面的不同位置的一系列角度测量进行。提出了一种空间映射的方法，提出了马关节软骨的双折射。比较从视觉健康和异常软骨样品获得的双折射带间隔的变化。可见骨关节炎病变的特征在于正常软骨所示的常规双折射带的损失。我们讨论了一些这些变化可能是由于组织内在结构的变化导致的。

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