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首页> 外文会议>NATO Advanced Research Workshop on Impact of Radiation Risk Estimates in Normal and Emergency Situations >ESTIMATION OF SOMATIC GENE MUTAGENESIS IN PATIENTS WITH BENIGN TUMORS LIVING IN RADIATION CONTAMINATED REGIONS WITH DIFFERENT ~(137)CESIUM DENSITY
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ESTIMATION OF SOMATIC GENE MUTAGENESIS IN PATIENTS WITH BENIGN TUMORS LIVING IN RADIATION CONTAMINATED REGIONS WITH DIFFERENT ~(137)CESIUM DENSITY

机译：不同〜（137）铯密度含有辐射污染区良性肿瘤患者体细胞基因诱变的体细胞基因诱变

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The aim of this study was to compare the level of somatic mutagenesis in women with benign tumors of the reproductive system living in radiation contaminated regions of the Russian Federation with that in unexposed healthy individuals. Frequency of peripheral blood lymphocytes bearing mutations at T-cell receptor (TCR) locus was assessed by flow cytometry in 219 patients with myoma who had been living in Novozibkovskiy, Klintsovskiy districts of Bryansk region and Uzlovaya district of Tula region for 17-19 years since the moment of the Chernobyl accident. Mean ~(137)Cs densities in these districts were 708, 322 and 171 kBq/m~2 accordingly. The control group included 42 age-matched unexposed healthy individuals. There was no significant elevation in the TCR mutant cell frequency in patients from Uzlovaya district which was contaminated with radionuclides at low level in comparison to controls. The frequency of the TCR-mutant cells was significantly higher in patients from the most contaminated district (Novozibkovskiy and Klintsovskiy) as compared to the control group by Mann-Whitney test (p<0.05). Median values were 4.3 ·10~(-4), 5.9·10~(-4), 3.8·10~(-4) accordingly. However, only 19% of the patients had the TCR-mutant cell frequencies exceeding the 95% confidence interval in the control group (>7,0·10~(-4)). The frequencies of mutant cells in other patients corresponded to those in the control group. Our results confirm that the TCR-method may be used for individual assessment of long-term health consequences after irradiation. Individuals with elevated TCR-mutant cell scores might belong to a high-risk group potentially prone to the development of neoplasm and need more thorough medical observation than the rest of population.
机译：本研究的目的是比较患有俄罗斯联邦辐射污染地区的生殖系统良性肿瘤的女性诱变水平，并在未暴露的健康个体中。通过居住在诺维佐地区克林斯克地区Klintsovskiy地区的Myoma患者，在219例肌瘤中，患有T细胞受体（TCR）基因座的外周血淋巴细胞突变的频率。切尔诺贝利事故的那一刻。平均值〜（137）这些地区的CS密度相应地为708,322和171 kBq / m〜2。该对照组包括42岁匹配的未暴露的健康个体。来自乌兹洛州地区的患者TCR突变体细胞频率没有显着升高，其在低水平的放射性核素污染，与对照组进行污染。与Mann-Whitney检验的对照组相比，来自最多受污染的地区（Novozibkovskiy和Klintsovskiy）的患者的TCR-突变细胞的频率显着更高（P <0.05）。相应的中值值为4.3·10〜（-4），5.9·10〜（-4），3.8·10〜（-4）。然而，只有19％的患者的TCR-突变细胞频率超过对照组的95％置信区间（> 7,0·10〜（-4））。突变细胞在其他患者中的频率对应于对照组的频率。我们的结果证实，TCR-Method可用于辐照后的长期健康后果的单独评估。具有升高的TCR - 突变体细胞分数的个体可能属于高风险的群体，可能易于肿瘤的发育，并且需要比其他人群更彻底的医学观察。

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