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首页> 外文会议>NATO Advanced Research Workshop on Pure and Applied Surface Chemistry and Nanomaterials for Human Life and Environmental Protection >THE INTERACTION OF NANOSTRUCTURED BIOMATERIALS WITH HUMAN CELL CULTURES. THE CHOICE OF CELL CULTURES FOR USE AS BIOCOMPATABILITY PROBES
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THE INTERACTION OF NANOSTRUCTURED BIOMATERIALS WITH HUMAN CELL CULTURES. THE CHOICE OF CELL CULTURES FOR USE AS BIOCOMPATABILITY PROBES

机译：纳米结构生物材料与人细胞培养物的相互作用。细胞培养物的选择用作生物相容性探针

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The study of the interaction of cells with nanoparticles or nanosurfaces is increasingly being performed using in vitro methods, largely with immortal cell lines. Immortal cell lines may behave differently from cells initially isolated from living tissue in these assays. Thus we have established a cell bank of primary human cell cultures stored at different stages from initial isolation through to senescence. We have examined the effects of culture age on proliferation upon carbon nanotube arrays, and adhesion to polystyrene surfaces. These data have been compared with an equivalent telomerase transformed line, and a commercially available line. Initial results suggest very large errors can be introduced into nanotoxicity and adhesion assays by inappropriate use of cell strains and lines.
机译：使用体外方法越来越多地进行细胞与纳米颗粒的相互作用的研究越来越多地进行，主要是具有不朽的细胞系。不朽的细胞系可以与最初从这些测定中的活组织中初始分离的细胞不同。因此，我们已经建立了储存在不同阶段的初级人细胞培养细胞库，从初始分离到衰老。我们研究了培养时代对碳纳米管阵列的增殖的影响，以及对聚苯乙烯表面的粘附性。已经将这些数据与当量的端粒酶转化线和市售的线进行了比较。初始结果表明，通过不适当地使用细胞株和线路，可以将非常大的误差引入纳米毒性和粘合测定中。

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