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首页> 外文会议>Materials Research Society Symposium on Biosurfaces and Biointerfaces >Increased Osteoblast Adhesion on Nanograined Hydroxyapatite and Tricalcium Phosphate Calcium Titanate Composites
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Increased Osteoblast Adhesion on Nanograined Hydroxyapatite and Tricalcium Phosphate Calcium Titanate Composites

机译：纳米羟基磷灰石和磷酸三钙钛合金复合材料上增加了成骨细胞粘附性

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Depending on the coating method utilized and subsequent heat treatments (such as through the use of plasma-spray deposition), inter-diffusion of atomic species across titanium (Ti) and hydroxyapatite (HA) coatings may result. These events may lead to structural and compositional changes that consequently cause unexpected HA phase transformations which may clearly influence the performance of an orthopedic implant. Thus, the objective of the present in vitro study was to compare the cytocompatibility properties of chemistries that may form at the Ti:HA interface, specifically HA, tricalcium phosphate (TCP), Ti doped HA, and those containing calcium titanate (CaTiO{sub}3). In doing so, results of this in vitro study showed that osteoblast adhesion increased with greater CaTiO{sub}3 substitutions in either HA or TCP. Specifically, osteoblast adhesion on HA and TCP composites with CaTiO{sub}3 was almost 4.5 times higher than over pure HA. Material characterization studies revealed that enhanced osteoblast adhesion on these compacts may be due to increasing shrinkage in the unit lattice parameters and consequent decrease in grain size. Although all CaTiO{sub}3 composites exhibited excellent osteoblast adhesion results, Ca{sub}9HPO{sub}4(PO{sub}4){sub}5OH phase formation into TCP/CaTiO{sub}3 increased osteoblast adhesion the most; due to these reasons, these materials should be further studied for orthopedic applications.
机译：取决于所使用的涂布方法和随后的热处理（例如通过使用等离子体喷雾沉积），可能导致钛（Ti）和羟基磷灰石（HA）涂层上的原子物种的间扩散。这些事件可能导致结构和组成变化，从而导致意外的HA相变，这可能显然影响整形外科植入物的性能。因此，本发明的体外研究的目的是比较可以在Ti：HA界面，特别是HA，磷酸氢（TCP），Ti掺杂的HA和含有钛酸钙（Catio {Sub）的磷酸钙的细胞凋亡性质3）。在这样做的情况下，这种体外研究的结果表明，骨喷粘度随着HA或TCP中的更大的CATIO {Sub} 3取代而增加。具体地，HA和TCP复合材料的骨质细胞粘附性与CATIO {sub} 3的粘附性比纯HA差异高4.5倍。材料表征研究表明，在这些压块上增强的成骨细胞粘附可以是由于单位晶格参数的收缩增加并且随后的晶粒尺寸的降低。虽然所有CATIO {亚} 3复合材料表现出优异的成骨细胞粘附结果，CA {亚} 9HPO {亚} 4（PO {SUB} 4）{SUB} 5OH相形成到TCP / CATIO {SUB} 3中提高了成骨细胞粘合性;由于这些原因，应进一步研究整形外科应用这些材料。

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