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首页> 外文会议>Conference on Skeletal Biology and Medicine >Effects of antiresorptive agents on osteomyelitis Novel insights into the pathogenesis of osteonecrosis of the jaw
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Effects of antiresorptive agents on osteomyelitis Novel insights into the pathogenesis of osteonecrosis of the jaw

机译：抗透射剂对骨髓炎骨髓炎骨髓炎发病机制的影响

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The effects of antiresorptive agents (e.g., alendronate [Aln], osteoprotegerin [OPG]) on bone infection are unknown. Thus, their effects on implant-associated osteomyelitis (OM) were investigated in mice using PBS (placebo), gentamycin, and etanercept (TNFR:Fc) controls. None of the drugs affected humoral immunity, angiogenesis, or chronic infection. However, the significant (P < 0.05 vs. PBS) inhibition of cortical osteolysis and decreased draining lymph node size in Aln- and OPG-treated mice was associated with a significant (P < 0.05) increase in the incidence of high-grade infections during the establishment of OM. In contrast, the high-grade infections in TNFR:Fc-treated mice were associated with immunosuppression, as evidenced by the absence of granulomas and presence of Gram~+ biofilm in the bone marrow. Collectively, these findings indicate that although antiresorptive agents do not exacerbate chronic OM, they can increase the bacterial load during early infection by decreasing lymphatic drainage and preventing the removal of necrotic bone that harbors the bacteria.
机译：抗再吸收剂（例如，阿仑膦酸盐[ALN]，骨保护素[OPG]）对骨感染的影响是未知的。 （：FC TNFR）控制。因此，它们对植入物相关的骨髓炎（OM）效应在小鼠中使用PBS（安慰剂），庆大霉素，和依那西普进行了调查。药物的无影响体液免疫，血管发生，或慢性感染。在ALN-和OPG处理的小鼠然而，显著（P <0.05，相对于PBS）抑制皮质骨溶解的和降低的引流淋巴结大小用显著（P <0.05）的高档感染发病期间增加相关建立OM的。相反，在TNFR高档感染：Fc处理小鼠用免疫抑制有关，通过不存在肉芽肿和革兰氏〜+生物膜存在于骨髓中所证明的。总的来说，这些研究结果表明，虽然抗骨吸收药物不会加剧慢性OM，他们可以通过降低淋巴引流，防止清除坏死骨头港口细菌的增加早期感染过程中细菌负荷。

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