• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>International Pharmaceutical Symposium >Preparation and in vitro evaluation of hydroxycamptothecin loaded transferrin modified stealth niosomes
【24h】

Preparation and in vitro evaluation of hydroxycamptothecin loaded transferrin modified stealth niosomes

机译：羟基美霉素的制备和体外评价加载转铁蛋白修饰隐身性憩室

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The aim was to prepare hydroxycamptothecin (HCPT) loaded transferrin modified stealth niosomes (Tf-PEG-NS) and to evaluate the physicochemical characteristics, cytotoxicity and cell uptake of Tf-PEG-NS. The amphiphilic copolymer of Poly (methoxy-polyethyleneglycol cyanoacrylate-con-hexadecyl cyanoacrylate) (PEG-PHDCA) acted as surface modified materials was synthesized and characterized. By coupling oxidized transferrin to PEG, Tf-PEG-NS were prepared by thin-film hydration-sonication dispersion method with particle size of (121.2±9.8)nm and encapsulation efficiency of (93.00±0.61)%. In vitro drug release of Tf-PEG-NS was up to 90% within 4B. In vitro cytotoxicity of Tf-PEG-NS was about 3 and 1.5 times that of HCPT injection and PEG-NS on KB cells, respectively. The relative uptake into nucleis of Tf-PEG-NS was significantly higher than other formulations, which was 79, 5.9 and 1.7 times that of HCPT injection, NS and PEG-NS respectively after 12h incubation. The in vitro results suggest that Tf conjugated PEG-coated niosomes could be a potentially effective HCPT delivery carrier for tumor therapy.
机译：其目的是制备羟基喜树碱加载的转铁蛋白修饰隐形泡囊（TF-PEG-NS），并评估TF-PEG-NS的物理化学特性，细胞毒性和细胞摄取。充当表面改性材料聚（甲氧基 - 聚乙二醇氰基丙烯酸酯-CON-十六烷基氰基丙烯酸酯）（PEG-PHDCA）的两亲共聚物的合成和表征。通过偶联氧化转到PEG，TF-PEG-NS是由薄膜水合 - 超声波分散法用的（93.00±0.61）％（121.2±9.8）nm和包封效率粒径制备。在TF-PEG-NS的体外药物释放达内4B 90％。在TF-PEG-NS的体外细胞毒性为约3和1.5倍HCPT注射和PEG-NS对KB细胞，分别。相对摄取到TF-PEG-NS的核团比其它制剂，其为79，5.9和1.7倍，HCPT注射，NS和PEG-NS的后分别孵育12小时更高显著。体外结果表明，TF缀合PEG涂覆类脂质体可以是用于肿瘤治疗潜在有效HCPT递送载体。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号