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首页> 外文会议>WSEAS International Conference on Mathematical Biology and Ecology >Solution Structure of Homeobox Transcription Factor Hex C-terminal Domain of Negatively Charged Activating Function
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Solution Structure of Homeobox Transcription Factor Hex C-terminal Domain of Negatively Charged Activating Function

机译：Homeobox转录因子六角形六端六端六端六角形域的溶液结构是带负电荷的激活功能

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摘要

Transcription factor Hex (haematopoietically expressed homeobox) is a homeobox protein that regulates differentiation and development of liver and monocyte. Hex consists of three functional domains, N-terminal proline rich domain, homeodomain and acidic C terminal domain. Other than DNA binding, the function of Hex is to repress and activate transcription of target genes using multiple mechanism. However, the structure and function of Hex-C terminal domain is not yet elucidated. Hence, the present structural studies were carried out by NMR spectroscopy in order to understand the function of the Hex-C domain. We deteremined the NMR assignment of backbone and side chains, and obtained 3D structure of Hex-C domain in the presence of GST tag. This is the first paper to present the structure of a protein with GST tag by NMR.
机译：转录因子十六进制（血尾表达Homeobox）是一种植物济症蛋白，调节肝脏和单核细胞的分化和发育。 Hex由三个功能域，N-末端脯氨酸富域，同型域和酸性C终端域组成。除DNA结合之外，Hex的功能是使用多种机制压制和激活靶基因的转录。但是，尚未阐明Hex-C终端域的结构和功能。因此，通过NMR光谱进行本发明的结构研究，以理解六克-C结构域的功能。我们在GST标签的存在下Deatemined对骨干和侧链的NMR分配，并获得了Hex-C域的3D结构。这是第一种用NMR呈现具有GST标签的蛋白质结构的纸张。

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